Xiaonan Zhang
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Group Leader, Associate Professor
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Recent Grants
Grant: Close
Lena Wäpplings Prize with research grand
Open Date: 2023-01-01
Close Date: 2024-01-01
Grant: Close
Swedish Childhood Cancer Fund
Open Date: 2023-01-01
Close Date: 2025-01-01
Grant: Close
Göran Gustafsson's research grant
Open Date: 2022-01-01
Close Date: 2025-01-01
Grant: Close
Jeanssons Stiftelse grant
Open Date: 2022-01-01
Close Date: 2024-01-01
Grant: Close
Swedish Childhood Cancer Fund for Research position (Forskarassistent)
Open Date: 2021-01-01
Close Date: 2025-01-01
Articles (9)
Quiescent Cancer Cells—A Potential Therapeutic Target to Overcome Tumor Resistance and Relapse
Quiescent cancer cells (QCCs) are nonproliferating cells arrested in the G0 phase, characterized by ki67low and p27high. QCCs avoid most chemotherapies, and some treatments could further lead to a higher proportion of QCCs in tumors. QCCs are also associated with cancer recurrence since they can re-enter a proliferative state when conditions are favorable. As QCCs lead to drug resistance and tumor recurrence, there is a great need to understand the characteristics of QCCs, decipher the mechanisms that regulate the proliferative–quiescent transition in cancer cells, and develop new strategies to eliminate QCCs residing in solid tumors. In this review, we discussed the mechanisms of QCC-induced drug resistance and tumor recurrence. We also discussed therapeutic strategies to overcome resistance and relapse by targeting QCCs, including (i) identifying reactive quiescent cancer cells and removing them via cell-cycle-dependent anticancer reagents; (ii) modulating the quiescence-to-proliferation switch; and (iii) eliminating QCCs by targeting their unique features. It is believed that the simultaneous co-targeting of proliferating and quiescent cancer cells may ultimately lead to the development of more effective therapeutic strategies for the treatment of solid tumors.
Year:
2023
Collaborators (6)
Fredrik Swartling
Associate Professor
Uppsala University
Stig Linder
Professor
Linköpings universitet Institutionen för klinisk och experimentell medicin
Tobias Sjöblom
Professor at Uppsala University
Uppsala University
Veronica Rendo
Uppsala University
Daniel Globisch
Professor
Uppsala University
Pádraig D'Arcy
Lecturer, Researcher
Linköping University

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