Yinglong Miao

Assistant Professor

University of Kansas

United States

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About

Dr. Yinglong Miao is an Assistant Professor at the University of Kansas, USA. His research areas focus on the structural biology and dynamics of G-protein-coupled receptors (GPCRs), including their activation mechanisms and interactions with small molecule ligands and peptides. Recent publications highlight advancements in cryo-electron microscopy and computational modeling techniques relevant to Alzheimer's disease and receptor signaling pathways.

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UNITED STATES

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Yinglong Miao

Research Interests

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About

Articles (25)

Emerging structures and dynamic mechanisms of γ-secretase for Alzheimer’s disease

Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR

Mechanistic studies of small molecule ligands selective to RNA single G bulges

Architecture and activation of single-pass transmembrane receptor guanylyl cyclase

Mechanisms of Peptide Agonist Dissociation and Deactivation of Adhesion G-Protein-Coupled Receptors

Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex

Mechanism of Ligand Binding to Theophylline RNA Aptamer

Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists

Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists

PepBinding: A Workflow for Predicting Peptide Binding Structures by Combining Peptide Docking and Peptide Gaussian Accelerated Molecular Dynamics Simulations

Ligand Gaussian Accelerated Molecular Dynamics 3 (LiGaMD3): Improved Calculations of Binding Thermodynamics and Kinetics of Both Small Molecules and Flexible Peptides

Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein

Deep Boosted Molecular Dynamics: Accelerating Molecular Simulations with Gaussian Boost Potentials Generated Using Probabilistic Bayesian Deep Neural Network

Predicting Biomolecular Binding Kinetics: A Review

Critical Non-Covalent Binding Intermediate for an Allosteric Covalent Inhibitor of SUMO E1

Ligand Gaussian Accelerated Molecular Dynamics 2 (LiGaMD2): Improved Calculations of Ligand Binding Thermodynamics and Kinetics with Closed Protein Pocket

Molecular Dynamics Activation of γ-Secretase for Cleavage of the Notch1 Substrate

Mechanistic Insights into Peptide Binding and Deactivation of an Adhesion G Protein-Coupled Receptor

Deep Learning Dynamic Allostery of G-Protein-Coupled Receptors

Structural basis of agonist specificity of α1A-adrenergic receptor

Correction to “Mechanism of Tripeptide Trimming of Amyloid β-Peptide 49 by γ-Secretase”

Mechanism of Tripeptide Trimming of Amyloid β-Peptide 49 by γ-Secretase

Gaussian Accelerated Molecular Dynamics in OpenMM

Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies

Mechanism of tethered agonist-mediated signaling by polycystin-1

Collaborators (5)

Yifan Cheng

Jingxin Wang

Michael Wolfe

Allan Haldane

Erik D. Holmstrom

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