Yutaka Taketani

We demonstrated that elevated intestinal luminal P i concentration can suppress intestinal Zn absorption activity without decreasing the expression of the associated Zn transporter. Increased intestinal luminal P i led to the formation of an insoluble complex with Zn while dietary P i restriction or administration of a P i binder ameliorated hypozincemia in chronic kidney disease model rats. Therefore, modulation of dietary P i by P i restriction or a P i binder might be useful for the treatment of hypozincemia and hyperphosphatemia.