Zachary Schug

Has grant

Assistant Professor

The Wistar Institute

United States

Research Interests

Explore related searches

Professors in United States Professors in Cancer Biology Cancer Biology professors in United States

Contact this professor

Get a free first email built on one of their papers, ready for you to edit and send yourself.

About

Dr. Zachary Schug is an Assistant Professor at the Wistar Institute in the United States. His research focuses on the metabolic pathways in cancer, particularly how acetate utilization rewires mitochondrial metabolism in malignancies such as acute myeloid leukemia and melanoma. He also studies the immunomodulatory effects of acetate in breast cancer and the role of neighborhood factors in disparities related to triple-negative breast cancer.

Recent Grants

Grant: Close

Targeting tumor metabolism to improve precision medicine

Open Date: 2019-11-01

Close Date: 2021-11-01

Grant: Close

The multifaceted role of acetate in cancer

Open Date: 2019-09-20

Close Date: 2024-06-30

Grant: Close

Targeting metabolic vulnerabilities associated with metastasis

Open Date: 2019-08-01

Close Date: 2022-07-14

Grant: Close

Targeting Acetyl CoA Synthetase (ACSS2) and in vivo probing of acetate metabolism in the treatment and diagnosis of colon, breast and prostate cancer

Open Date: 2015-01-01

Close Date: 2016-12-31

Articles (19)

Year:

2024

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2020

Year:

2020

Collaborators (9)

Shuai Wu

The Wistar Institute

UNITED STATES

View details

Takami Sato

Thomas Jefferson University

UNITED STATES

View details

michela perego

Research Assistant Professor

The Wistar Institute

UNITED STATES

View details

Gyorgy Hajnoczky

Professor

Thomas Jefferson University

UNITED STATES

View details

Jesse Berman

Assistant Professor

University of Minnesota School of Public Health

UNITED STATES

View details

Toshitha Kannan

The Wistar Institute

UNITED STATES

View details

Vivian Chua

Lecturer

Edith Cowan University

AUSTRALIA

View details

J. William Harbour

Professor and Chair

University of Texas Southwestern Medical Center

UNITED STATES

View details

Ronny Drapkin

Associate Professor

University of Pennsylvania

UNITED STATES

View details

ApplyKite TwinLearns as you apply

Make your next move.

Prepare your application

Review drafts before you send them.

Zachary Schug

Research Interests

Explore related searches

Contact this professor

About

Recent Grants

Articles (19)

ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis

Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth

Syntaphilin Regulates Neutrophil Migration in Cancer

Neighborhood factors and triple negative breast cancer: The role of cumulative exposure to area‐level risk factors

Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer

Syntaphilin Regulates Neutrophil Migration in Cancer.

Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma.

Racial disparities in triple negative breast cancer: toward a causal architecture approach.

Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth.

A Population Health Assessment in a Community Cancer Center Catchment Area: Triple-Negative Breast Cancer, Alcohol Use, and Obesity in New Castle County, Delaware

Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma

Targeting cancer metabolism in the era of precision oncology.

Metabolic adaptation to the chronic loss of Ca<sup>2+</sup> signaling induced by KO of IP<sub>3</sub> receptors or the mitochondrial Ca<sup>2+</sup> uniporter.

A Population Health Assessment in a Community Cancer Center Catchment Area: Triple-Negative Breast Cancer, Alcohol Use, and Obesity in New Castle County, Delaware.

Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma.

Targeting acetate metabolism: Achilles' nightmare.

Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth.

BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors.

Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser.

Collaborators (9)

Shuai Wu

Takami Sato

michela perego

Gyorgy Hajnoczky

Jesse Berman

Toshitha Kannan

Vivian Chua

J. William Harbour

Ronny Drapkin

Make your next move.