Zbynek Heger

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Associate Professor

Mendel University in Brno

Czech Republic

Research Interests

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About

Zbynek Heger is an Associate Professor at Mendel University in Brno, Czech Republic. His research areas focus on the intersection of biomedical applications and materials science, with recent publications addressing topics such as the therapeutic potential of ferroptosis in cholangiocarcinoma, metabolic reprogramming in rheumatoid arthritis, and innovative drug delivery systems. His work also explores biotechnological solutions for antibiotic resistance and the role of the gut microbiota in immunity.

Recent Grants

Grant: Open

Hybrid biocompatible nanocatalysts for extracellular bioorthogonal activation of prodrugs

Open Date: 2023-01-01

Close Date: 2027-12-01

Grant: Close

Ferritin as a tool for enzymes-directed prodrug activation

Open Date: 2021-05-01

Close Date: 2024-12-01

Grant: Close

MENDELU Rector’s Awards for the outstanding achievements in the field of natural and technical sciences

Open Date: 2020-09-01

Close Date: 2020-09-01

Grant: Close

Encapsulation of cholinesterase reactivators using apoferritin for enhanced bioavailability in central nervous system

Open Date: 2019-01-01

Close Date: 2021-12-01

Grant: Close

Comprehensive insight into the mechanisms of action and metabolism of tyrosine kinase inhibitors and a study of ways increasing their antitumor efficiency

Open Date: 2018-01-01

Close Date: 2020-12-01

Articles (22)

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Brno University of Technology

CZECH REPUBLIC

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Dipl.-Ing. Dr. Cristian-Tudor Matea

University of Salzburg

AUSTRIA

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Zbynek Heger

Research Interests

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About

Recent Grants

Articles (22)

Centrifugally spun and ZnO-infiltrated PVA fibers with antibacterial activity for treatment of Acne vulgaris

Microrobots for Antibiotic-Resistant Staphylococcus aureus Skin Colony Eradication

N-(5-(2-morpholino-4-oxo-3,4-dihydroquinazolin-8-yl)pyridin-2-yl)acylamides as novel multi-PI3K/DNA-PK/P-gp inhibitors for efficient chemosensitization and MDR alleviation

Role of CNNM4 in the progression of cholangiocarcinoma: implications for ferroptosis and therapeutic potential

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Streamlined metal-based hydrogel facilitates stem cell differentiation, extracellular matrix homeostasis and cartilage repair in male rats

Biomedical applications of mammalian, bacterial, and archaeal ferritins – Targeted drug delivery and beyond

Translational nanorobotics breaking through biological membranes

Biopolymeric fibers prepared by centrifugal spinning blended with ZnO nanoparticles for the treatment of Acne vulgaris

Engineered human H-chain ferritin with reversed charge of the internal cavity exhibits RNA-mediated spongelike effect for loading RNA/DNA-binding molecules

Pulling the Rug Out from Under: Biomechanical Microenvironment Remodeling for Induction of Hepatic Stellate Cell Quiescence

Age-associated changes in innate and adaptive immunity: role of the gut microbiota

Remodeling of the liver fibrosis microenvironment based on nilotinib-loaded multicatalytic nanozymes with boosted antifibrogenic activity

A “2 + 2” strategy for tumor immune microenvironment remodeling based on complementary immune checkpoint blockade

Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology

Orally Administrable H <sub>2</sub> S‐Scavenging Metal‐Organic Framework Prepared by Co‐Flow Microfluidics for Comprehensive Restoration of Intestinal Milieu

Enhanced macrophage polarization induced by COX-2 inhibitor-loaded Pd octahedral nanozymes for treatment of atherosclerosis

A color-tunable single-benzene fluorophore-based sensor for sensitive detection of palladium in solution and living cells

EVAnalyzer: High content imaging for rigorous characterisation of single extracellular vesicles using standard laboratory equipment and a new open‐source ImageJ/Fiji plugin

Efficient Protein Transfection by Swarms of Chemically Powered Plasmonic Virus-Sized Nanorobots

Tuning the Surface Coating of IONs Toward Efficient Sonochemical Tethering and Sustained Liberation of Topoisomerase II Poisons [Corrigendum]

Passive Diffusion vs Active pH-Dependent Encapsulation of Tyrosine Kinase Inhibitors Vandetanib and Lenvatinib into Folate-Targeted Ferritin Delivery System

Collaborators (13)

Vladimir Pekarik

Martin Kormunda

Pavan Kumar Chennam

Nicole Meisner-Kober

Jan Pribyl

Anna Jancik-Prochazkova

Ondrej Zitka

Miguel Angel Merlos Rodrigo

David Malinak

Lukas Richtera

Christian G. Huber

Jan Macak

Dipl.-Ing. Dr. Cristian-Tudor Matea

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