David Malinak

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Assistant Professor

University of Hradec Kralove, Faculty of Science

Czech Republic

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About

David Malinak is an Assistant Professor at the University of Hradec Kralove, Faculty of Science in the Czech Republic. His research focuses on the development and evaluation of reactivators for organophosphate-inhibited cholinesterases, as well as novel inhibitors for multi-PI3K/DNA-PK/P-gp pathways. Recent publications include work on the synthesis of halogenated compounds and their impact on neuroprotection and drug resistance.

Recent Grants

Grant: Close

Modified nucleophiles for reactivation of cholinesterases inhibited by organophosphorus compounds

Open Date: 2021-01-01

Close Date: 2023-12-01

Grant: Close

Preparation and in vitro testing of HLö7 - universal reactivator of inhibited acetylcholinesterase

Open Date: 2017-01-01

Close Date: 2017-12-01

Articles (17)

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2025

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2025

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2024

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

Collaborators (9)

Miroslav Lísa

University of Hradec Králové

CZECH REPUBLIC

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Marketa Chvojkova

National Institute of Mental Health

CZECH REPUBLIC

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Zbynek Heger

Associate Professor

Mendel University in Brno

CZECH REPUBLIC

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Alžběta Dlabková

CZECH REPUBLIC

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Monika Schmidt

Assistant professor

University of Hradec Kralove, Faculty of Science

CZECH REPUBLIC

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Oleksandr Kozlov

assistant professor

University of Hradec Králové

CZECH REPUBLIC

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Jaroslav Pejchal

Chief of toxicology group/associate professor

CZECH REPUBLIC

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Kamil Musilek

CZECH REPUBLIC

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Adam Skarka

University of Hradec Kralove, Faculty of Science

CZECH REPUBLIC

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David Malinak

Research Interests

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About

Recent Grants

Articles (17)

Non-oxime reactivators of organophosphate-inhibited cholinesterases

N-(5-(2-morpholino-4-oxo-3,4-dihydroquinazolin-8-yl)pyridin-2-yl)acylamides as novel multi-PI3K/DNA-PK/P-gp inhibitors for efficient chemosensitization and MDR alleviation

Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents

Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition

Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases

Halogenated monopyridinium oximes are less effective in reactivation of phosphylated cholinesterases than bisquaternary oximes

Reactivators of butyrylcholinesterase inhibited by organophosphorus compounds

Direct Chiral Supercritical Fluid Chromatography–Mass Spectrometry Analysis of Monoacylglycerol and Diacylglycerol Isomers for the Study of Lipase-Catalyzed Hydrolysis of Triacylglycerols

Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK)

Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells

Strategies for enhanced bioavailability of oxime reactivators in the central nervous system

BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS

STAT3 inhibitor Stattic and its analogues inhibit STAT3 phosphorylation and modulate cytokine secretion in senescent tumour cells

Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides

Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870

Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents

Optimization of gradient reversed phase high performance liquid chromatography analysis of acetaminophen oxidation metabolites using linear and non-linear retention model

Collaborators (9)

Miroslav Lísa

Marketa Chvojkova

Zbynek Heger

Alžběta Dlabková

Monika Schmidt

Oleksandr Kozlov

Jaroslav Pejchal

Kamil Musilek

Adam Skarka

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