The University of Cambridge is offering a prestigious Marie Curie PhD Studentship as part of the MetaExplore network, focusing on functional metagenomics and the discovery of novel biocatalysts for a sustainable circular economy. The project, led by Professor Florian Hollfelder in the Department of Biochemistry, aims to harness environmental sources for new catalysts that can be applied in recycling, bioremediation, and green chemistry. Research will involve ultrahigh throughput screening of metagenomic libraries using microfluidic picoliter droplets, enabling experimental interrogation of enzyme libraries with over 10 million members per day. Candidate enzymes will be mechanistically investigated, structurally characterized, and improved through directed evolution.

This studentship provides a unique opportunity to work in an international research environment, collaborating with various EU and UK groups within the MetaExplore network. The training includes both experimental and computational work, with a wide range of skill development in molecular biology, chemical biology, assay development, enzyme kinetics, DNA library generation, structural biology, organic synthesis, high-throughput screening, mechanistic enzymology, bioinformatics, and microfluidic engineering.

Applicants should hold a first or upper second class degree in chemistry, biochemistry, or a related subject, followed by a PhD. Experience in relevant laboratory techniques and research areas is highly desirable. The position is fully funded for three years, with support for tuition and research costs, and offers excellent career development opportunities in advanced molecular and biochemical research.

To apply, candidates should submit a cover letter describing their research interests, a detailed CV including exam marks and practical experience, a list of publications, and the names and email addresses of at least two referees familiar with their research work. Applications are to be submitted online via the University of Cambridge recruitment system, quoting reference PH48176. The deadline for applications is 2 January 2026. For informal enquiries, contact Professor Florian Hollfelder at [email protected].

This opportunity is ideal for motivated, research-driven candidates seeking to advance their careers in functional metagenomics, biochemistry, and sustainable science within a world-class academic environment.