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Centre for Genomic Regulation

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CRG Fellowships 2026/2027

Master Fellowship in Probabilistic Machine Learning and Genomics: Protein Variant Effects Centre for Genomic Regulation in Spain

Degree Level

Master's

Field of study

Computer Science

Funding

The fellowship provides a gross stipend of €700 per month for up to four months, plus return-travel support of up to €1,000 for non-European flights or €400 for European flights. It must take place during the 2026/2027 academic year.

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Country

Spain

University

Centre for Genomic Regulation

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Keywords

Computer Science
Biophysics
Biology
Computational Biology
Genetic
Protein Folding
Genomic
Bioinformatic
Protein Stability
Physics
ML

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About this position

The Centre for Genomic Regulation (CRG) offers a master's fellowship in the Dias & Frazer Lab focused on probabilistic machine learning and genomics. The project, “Folding versus function: disentangling the molecular mechanisms of missense variants in gene-trait associations,” examines how genetic variants alter protein stability and biological function.

The student will integrate protein language models with protein-folding energetics to distinguish mutations that destabilize proteins from those that preserve stability but affect functions such as allostery, ligand or partner binding, and downstream interactions. The work will use evolutionary free-energy estimates, physical folding free energies and the concept of protein “dark energy” to analyse the mechanistic consequences of missense variants.

The project will apply this computational and biophysical framework to genotype-phenotype summary statistics from the UK Biobank, provided through Genebass, with a focus on genes associated with blood-biochemistry biomarkers. Predicted changes in folding stability and dark energy will be related to variant effect sizes and compared with putative loss-of-function effects.

The student will join an international CRG research environment with access to advanced core technologies, seminars and complementary skills training. The research combines computational biology, machine learning, human genetics, protein biophysics, bioinformatics and variant-effect prediction.

Funding details

The fellowship provides a gross stipend of €700 per month for up to four months, plus return-travel support of up to €1,000 for non-European flights or €400 for European flights. It must take place during the 2026/2027 academic year.

What's required

Applicants must be enrolled in an official undergraduate or MSc programme at a university, because an agreement must be signed between the university and the Centre for Genomic Regulation. The project seeks a motivated master's student with a background in bioinformatics, computational biology, computer science, physics, mathematics or a related quantitative discipline. Previous programming experience in Python is expected. Familiarity with molecular biology, genetics, statistics or machine learning is desirable but not required. The fellowship is available only to new recruits, not students already at the CRG.

How to apply

Review the project and contact the project supervisor and group leader. Email a motivation letter, CV, reference letter and university transcripts to Ezequiel Galpern and Jonathan Frazer using the provided email link.

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