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Technical University of Denmark

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PhD scholarship in biosynthesis of de novo proteins and peptides for PFAS-free biomaterials Technical University of Denmark in Denmark

Degree Level

PhD

Field of study

Biochemistry

Funding

Available

Deadline

Dec 6, 2026

Country flag

Country

Denmark

University

Technical University of Denmark

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Keywords

Biochemistry
Chemistry
Materials Science
Biotechnology
Biology
Synthetic Biology
High-throughput Screening
Automation
Material Characterization
Protein Engineering
Microbial Biotechnology
Biomaterials

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About this position

This PhD project is part of BRIGHT’s mission-oriented programme on novel biomanufacturing-enabled materials. The work aims to create a general platform for designing protein- and peptide-based biomaterials, using solid-state battery components as the first testbed and focusing on alternatives to fluorinated PFAS polymers.

The successful candidate will help move de novo molecular designs from the computer into the laboratory. The project centres on producing canonical and non-canonical proteins and peptides by biosynthesis in microbial hosts, then preparing them for structural characterisation and materials testing.

You will collaborate closely with computational researchers and chemists in an iterative design-build-test-learn workflow. A major part of the work is to synthesise and express DNA-encoded protein and peptide libraries, support rapid laboratory feedback to improve generative models, and contribute to the development of protocols and automated laboratory systems.

The position is based at BRIGHT – The Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition at the Technical University of Denmark. The broader research environment combines AI-guided protein and peptide design, microbial engineering, non-canonical amino acid biosynthesis and incorporation, fermentation, purification, materials processing, analytical quality control, and structure-function characterisation.

The role also includes developing and optimising expression and synthesis workflows, managing strain, plasmid and building-block supplies, and working on parallelisation and automation strategies to scale up the laboratory pipeline. The student is expected to report results in publications and conferences, collaborate across networks, and contribute to teaching and supervision activities within the group.

Funding details

Available

What's required

Applicants must hold an MSc in biotechnology, biochemistry, chemistry or a related area, or an equivalent two-year master's degree (120 ECTS). Required experience includes hands-on recombinant protein production in microbial hosts, including expression and purification, and biochemical and biophysical characterisation. Excellent written and spoken English is required, along with careful, organised laboratory practice and good teamwork. Preferred but not mandatory: experience with computational de novo protein design tools such as RFdiffusion, ProteinMPNN, LigandMPNN, RoseTTAFold or AlphaFold; analytical methods such as HPLC and mass spectrometry; non-canonical amino acid chemistry; and experience in integrated computational and wet-lab teams.

How to apply

Submit the complete application online no later than 6 December 2026 at 23:59 Danish time. Upload all materials as one PDF in English through the 'Apply now' portal. Include a motivation letter, CV, grade transcripts, BSc/MSc diploma with grading scale, and one reference letter with referee contact details.

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