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University of Birmingham
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PhD Studentship: Mechanistic Modelling of Biofilm-Induced Host-Cell Damage University of Birmingham in United Kingdom
Degree Level
PhD
Field of study
Inflammation
Funding
Available
Deadline
Nov 23, 2026
Country
United Kingdom
University
University of Birmingham
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About this position
This PhD studentship at the University of Birmingham develops a mechanistic mathematical framework to explain how biofilm-associated infections lead to host-cell damage. The project focuses on the coupled biology of biofilm growth, nutrient transport, bacterial toxins, reactive oxygen species, inflammatory signalling, DNA damage, repair failure, and host-cell viability.
The student will build and analyse models that connect biofilm structure with local biochemical gradients and tissue injury across space and time. A key part of the project is to create efficient computational methods for simulating these interacting processes as the biofilm changes, and to use experimental observations to estimate hidden parameters and test competing damage pathways.
The research is explicitly aimed at integrating modelling with experiments: the calibrated framework will be used to identify informative measurements, guide sampling strategies, and predict responses to selected therapeutic interventions that can then be evaluated in independent experiments. Overall, the project seeks an experimentally validated explanation of which mechanisms dominate host-cell injury in biofilm infections and how those mechanisms can be targeted while preserving effective bacterial control.
Funding details
Available
How to apply
Apply by email to [email protected] using the application link provided. Check the linked funding and eligibility page for full details before submitting.
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