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University of Birmingham

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PhD Studentship: Mechanistic Modelling of Biofilm-Induced Host-Cell Damage University of Birmingham in United Kingdom

Degree Level

PhD

Field of study

Inflammation

Funding

Available

Deadline

Nov 23, 2026

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Country

United Kingdom

University

University of Birmingham

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Keywords

Inflammation
Computer Science
Biomedical Engineering
Biology
Mathematics
Oxidative Stress
Mathematical Modeling
Systems Biology
Uncertainty Analysis
Medical Science
Dna Damage
Statistics

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About this position

This PhD studentship at the University of Birmingham develops a mechanistic mathematical framework to explain how biofilm-associated infections lead to host-cell damage. The project focuses on the coupled biology of biofilm growth, nutrient transport, bacterial toxins, reactive oxygen species, inflammatory signalling, DNA damage, repair failure, and host-cell viability.

The student will build and analyse models that connect biofilm structure with local biochemical gradients and tissue injury across space and time. A key part of the project is to create efficient computational methods for simulating these interacting processes as the biofilm changes, and to use experimental observations to estimate hidden parameters and test competing damage pathways.

The research is explicitly aimed at integrating modelling with experiments: the calibrated framework will be used to identify informative measurements, guide sampling strategies, and predict responses to selected therapeutic interventions that can then be evaluated in independent experiments. Overall, the project seeks an experimentally validated explanation of which mechanisms dominate host-cell injury in biofilm infections and how those mechanisms can be targeted while preserving effective bacterial control.

Funding details

Available

How to apply

Apply by email to [email protected] using the application link provided. Check the linked funding and eligibility page for full details before submitting.

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