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CNRS

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Doctorant en Neurosciences (H/F) en neurobiologie : inflammation systémique, métabolisme des monoamines et nociception CNRS in France

Degree Level

PhD

Field of study

Biology

Funding

Available

Deadline

Nov 26, 2026

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Country

France

University

CNRS

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Keywords

Biology
Neuropsychology
Neuroinflammation
Medical Science
Pharmacy
Microglia

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About this position

This PhD project explores how systemic inflammation during sepsis can alter brain function through glial activation and changes in monoamine metabolism. The work is centered on a neurobiological mechanism linking neuroinflammation, the aryl hydrocarbon receptor (AhR), and the UDP-glucuronosyltransferase UGT1A6a in astrocytes.

The advertised research builds on preliminary evidence that glial cells can glucuronidate morphine, that LPS increases this activity in vitro and in vivo, and that this effect is reduced by AhR inhibition. The project also points to a broader metabolic impact in the brain, including the presence of serotonin-glucuronide after LPS treatment and the possible contribution of altered neurotransmitter handling to sepsis-associated encephalopathy and hyperalgesia.

The doctoral researcher will study the functional axis between neuroinflammation, glial cells, AhR signaling, and UGT1A6a-dependent glucuronidation, with a particular focus on astrocytes. The goal is to understand how these pathways may influence neurotransmitter levels and pain-related responses in the context of sepsis.

The position is offered by CNRS in France and is embedded in a neuroscience/neurobiology research environment focused on the cellular and molecular basis of inflammatory brain dysfunction.

Funding details

Available

How to apply

Apply through the listed public service application link. Follow the instructions on the portal and submit the requested application materials before the deadline.

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