IC-3-7 Rewiring Mammalian Cells Metabolism to Enable Sustainable On-Demand Biomanufacturing (PhD) Imperial College London in United Kingdom

This PhD opportunity, hosted by the Centre for Doctoral Training in Green Industrial Futures (CDT-GIF) at Imperial College London, focuses on rewiring mammalian cell metabolism to enable sustainable, on-demand biomanufacturing. The project addresses the scalability and sustainability challenges of mammalian cell-based biomanufacturing, which is crucial for applications such as therapeutic protein production and cultivated meat. Current limitations include high costs, environmental impact, and reduced yields due to genetic engineering and complex media requirements.

The research integrates synthetic biology, genome engineering, metabolic modelling, and process and life cycle analysis to develop new mammalian cell chassis optimized for sustainability. The CDT-GIF programme is designed for top-performing junior researchers and offers a four-year funded studentship starting September 2026. Students benefit from expert training, residential taught courses at partner universities, and opportunities to contextualize their research within the broader net zero landscape. Additional features include international placements, work experience with industrial partners, and a bespoke net-zero leadership programme.

Applicants should hold a First-class or 2:1 MEng or MSc with merit (over 60%) in Chemical Engineering, Process Engineering, Chemistry, Materials Science, Geoscience, or related fields. Candidates with a relevant MA for socio-politico-economic topics or a First-class BSc/BEng (Hons) with significant industry/research experience may also be considered. Experience in bacterial and mammalian cell culturing, molecular cloning, synthetic biology, and modelling is highly desirable. Candidates must meet Imperial College London’s entry requirements.

Funding includes full UK fees, a tax-free stipend (£20,780 for 2025/2026 plus ~£2,000 London weighting), and a budget for travel and consumables. The CDT is funded by the UK Engineering and Physical Sciences Research Council and supported by industrial partners, providing access to a wide range of academic expertise and facilities.

Applications are accepted year-round. For further information, visit the CDT-GIF website or contact [email protected]. The programme offers a unique opportunity to contribute to the future of sustainable industrial biomanufacturing and net zero innovation.