Medicinal Chemistry PhD Project: Synthesis and biological evaluation of small molecules to target mesothelioma and related ASS1-dependent tumours University of Surrey in United Kingdom

Funded PhD project in telomere biology , cancer biology , peptide design , protein biochemistry , molecular biology , cell biology , and synthetic/pharmaceutical chemistry at the MRC Laboratory of Medical Sciences and Imperial College London in London, United Kingdom . The project asks how cells replicate chromosome ends while preserving telomere protection. You will study the shelterin complex, TRF2 interactions, and the origin recognition complex (ORC), with a focus on how disrupting these int...

PhD opportunity: Sustainable Synthesis for Medicinal Chemistry in 3-Dimensions: Bioisosteres, PROTAC Linkers, Scaffold Hopping and Unnatural Amino Acids. This project is offered through the EPSRC Centre for Doctoral Training in Chemical Synthesis for a Healthy Planet (CSHP CDT), a fully funded 4-year PhD programme jointly delivered by the Universities of Oxford and York. The project is primarily based at the University of York , Department of Chemistry, and is supervised by Prof Peter O’Brien wi...

PhD opportunity: Development of new-to-nature enzymatic reactivity for applications in organic synthesis at the University of Cambridge , Department of Chemistry, in the Mateo Sanchez Lab. The project sits at the interface of chemistry and biology and focuses on discovering and developing new-to-nature reactivity using engineered enzymes. Research activities include substrate synthesis using traditional synthetic chemistry, screening campaigns to identify and optimise enzymatic activity, structu...

The University of Cambridge is inviting applications for PhD research opportunities in synthetic chemistry within the Yusuf Hamied Department of Chemistry. Seven internationally leading research groups offer projects spanning reaction discovery, catalysis, molecular design, chemical biology, supramolecular chemistry, and computation. The research community focuses on inventing new reactions, discovering catalysts, understanding molecular behaviour, and developing tools with applications in biolo...

Fully funded PhD opportunity in medicinal chemistry at Newcastle University , within the Newcastle Medicinal Chemistry Group. The project focuses on high-throughput chemistry and direct-to-biology screening , with supervision involving Mike Waring and Hannah Stewart, and collaboration with Charles A. and Liz McFaddin at Eli Lilly and Company . This is a research-focused doctoral opening for candidates interested in drug discovery, screening workflows, and modern medicinal chemistry approaches. T...