Masaryk University
1 week ago
PhD Candidate in Structural Biology of Wnt Signaling at Masaryk University Masaryk University in Czech Republic
Degree Level
PhD
Field of study
Biochemistry
Funding
Full-time contract with an attractive salary. Benefits include open access to CEITEC MU core facilities, flexible working hours, support for further education and professional development, 6 weeks of paid holiday, medical insurance, financial contribution to meal and kindergarten/pension scheme, Multisport card, mental health care, sports lessons on campus, and kindergarten on campus.
Deadline
Dec 23, 2026
Country
Czech Republic
University
Masaryk University
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About this position
CEITEC MU at Masaryk University in Brno, Czech Republic is recruiting a PhD Candidate in (Un) Structural Biology of Wnt Signaling in the Konstantinos Tripsianes Research Group.
The project focuses on Wnt signaling and the central hub protein Dishevelled (DVL), with emphasis on how conformational plasticity, phosphorylation, partner binding, self-assembly, and intrinsic disorder regulate signal routing. The research combines structural biology and biophysical approaches including NMR, X-ray, cryo-EM, FRET, ITC, and BLI, together with cellular readouts such as TopFlash and BRET and proteomics.
Candidates may choose among three open questions related to DVL function: whether disorder expands the functional space of structured domains, whether phosphorylation follows a direction/order/hierarchy across S/T sites and clusters, and how intrinsic disorder relates to liquid-liquid phase separation and droplet formation.
Applicants should hold an MSc degree (preferably in Life Sciences) and have a strong interest in structural biology and biomolecular NMR. Experience in structural biology, biochemistry, and molecular biology methods is required, along with good English communication skills, teamwork, and a motivated, curiosity-driven mindset. Programming skills are a plus.
The position is full-time with an attractive salary and access to CEITEC MU core facilities. Benefits include flexible working hours, professional development support, paid holiday, medical insurance, meal and pension/kindergarten contributions, Multisport card, mental health care, sports lessons, and on-campus kindergarten.
Deadline: 23 December 2026. Start date: immediately or upon agreement. Applications should include a CV, publication list, and motivation letter with contact details for at least two references, and must be submitted through the e-application portal.
Funding details
Full-time contract with an attractive salary. Benefits include open access to CEITEC MU core facilities, flexible working hours, support for further education and professional development, 6 weeks of paid holiday, medical insurance, financial contribution to meal and kindergarten/pension scheme, Multisport card, mental health care, sports lessons on campus, and kindergarten on campus.
What's required
MSc degree, preferably in Life Sciences; strong interest in structural biology and biomolecular NMR applications; experience in structural biology, biochemistry, and molecular biology methods; English proficiency in speaking and writing; good communication and interpersonal skills; team-player attitude; motivation and curiosity-driven mindset. Programming skills are a plus.
How to apply
Submit the application via the e-application portal with a CV, list of publications, and a motivation letter including contact details for at least two references. If there are issues with the portal, contact HR Darja Horáková by email.
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