PhD in Lysosomal TMEM106B in Brain Ageing and Disease Medical Research Council (Cambridge) Laboratory of Molecular Biology in United Kingdom

PhD opportunity in protein maturation, quality control, and disease at the Medical Research Council (Cambridge), Laboratory of Molecular Biology with Dr R Hegde . This project sits at the intersection of cell biology , molecular biology , and structural biology . The group studies how mammalian cells produce, insert, fold, and assemble membrane proteins such as GPCRs, transporters, receptors, and ion channels, and how cells recognize and degrade unassembled “orphan” proteins to maintain cellular...

PhD opportunity at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom on structural and cellular approaches to understand microtubule motors . This project sits at the intersection of cell biology , molecular biology , and structural biology , with a strong focus on microtubule motors such as dynein and kinesin . The research asks how motors are linked to cargos and coordinated to deliver organelles, RNAs, and proteins to the correct destination, especially...

PhD opportunity in Protein Aggregates and Neurodegeneration at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, with Dr H McMahon. This project explores how protein aggregates accumulate, become toxic to brain cells, and spread in neurodegenerative disease. Two related PhD projects are available in the McMahon group. One focuses on aggregate uptake mechanisms , including Aggregation-Dependent Endocytosis, receptor identification, aggregate size effects, and ways to prev...

PhD opportunity in pathological protein assembly in neurodegenerative diseases at the Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom . The project is centered on the molecular pathology of neurodegeneration, with a focus on amyloid filament formation by disease-associated proteins such as TDP-43 , annexin A11 , and TAF15 . Two PhD project directions are described. One aims to reproduce pathological protein filament structures in vitro using protein biochemist...

The University of Arizona’s R. Ken Coit College of Pharmacy, Department of Pharmacology and Toxicology, is recruiting a Postdoctoral Research Associate I in Dr. Xinglong Wang’s lab in Tucson, Arizona, United States. The lab studies the pathomechanisms of TDP-43 neurotoxicity and mitochondrial dysfunction in neurodegeneration . The successful candidate will join a research environment focused on cutting-edge neuroscience and disease-mechanism work, with opportunities for strong training, manuscri...