PhD in Structural and Cellular Approaches to Understand Microtubule Motors Medical Research Council Laboratory of Molecular Biology in United Kingdom

PhD opportunity: Lysosomal TMEM106B in brain ageing and disease at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, Cambridge, United Kingdom. This project with Dr Diana Arseni explores how the lysosomal protein TMEM106B forms amyloids in the brain in an age-dependent manner and how TMEM106B genetic variants may influence healthy ageing and disease risk in frontotemporal lobar degeneration and Alzheimer’s disease . The research is centered on lysosomal biology , brain a...

PhD opportunity in pathological protein assembly in neurodegenerative diseases at the Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom . The project is centered on the molecular pathology of neurodegeneration, with a focus on amyloid filament formation by disease-associated proteins such as TDP-43 , annexin A11 , and TAF15 . Two PhD project directions are described. One aims to reproduce pathological protein filament structures in vitro using protein biochemist...

PhD opportunity in AMPA receptor structure and function at the Medical Research Council (Cambridge), Laboratory of Molecular Biology in the United Kingdom . This project sits at the intersection of neuroscience , molecular biology , and structural biology , focusing on how AMPA glutamate receptors (AMPA-Rs) and their auxiliary proteins shape excitatory synaptic transmission, plasticity, and information storage in the brain. The lab aims to decode AMPAR signalling complexity from atomic structure...

PhD opportunity in the macromolecular basis of nuclear remodelling in humans at the Medical Research Council (Cambridge), Laboratory of Molecular Biology. This project in structural biology , cell biology , and molecular biology explores how the nucleus is reshaped by cytoskeletal filaments in human cells and how this architecture contributes to cell migration, tissue formation, immune response, and cancer progression. The lab is especially interested in the high-order organisation of the cytosk...

PhD opportunity in protein maturation, quality control, and disease at the Medical Research Council (Cambridge), Laboratory of Molecular Biology with Dr R Hegde . This project sits at the intersection of cell biology , molecular biology , and structural biology . The group studies how mammalian cells produce, insert, fold, and assemble membrane proteins such as GPCRs, transporters, receptors, and ion channels, and how cells recognize and degrade unassembled “orphan” proteins to maintain cellular...