PhD in Mitochondrial Genetic Determinants of Multiple Sclerosis University of Cambridge in United Kingdom

University of Cambridge is hiring for 2 Postdoc and 1 Research Assistant positions in the Department of Clinical Neurosciences , within an Aligning Science Across Parkinson's (ASAP) -funded project. The project focuses on Parkinson’s disease progression and aims to unravel the molecular mechanisms underlying disease progression using cutting-edge spatial multi-omics approaches in human post-mortem brain tissue . This opportunity sits at the intersection of neuroscience , neuropathology , molecul...

PhD opportunity at the University of Cambridge in Mathematical Modelling of Neurodegenerative Tauopathies – from systems to clinical impact. This project sits in the Department of Clinical Neurosciences and is supervised by Dr T Rittman . It builds on in silico mathematical models of neurodegenerative disorders associated with the tau protein and uses real-world cohort data from people with Progressive Supranuclear Palsy , Corticobasal Syndrome , and Frontotemporal Dementia . The research combin...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on retrograde mitochondrial signalling, epigenetic reprogramming, glial toxicity, and neuroinflammation in progressive multiple sclerosis . The project focuses on how mitochondrial dysfunction and mitochondrial stress trigger nuclear signalling and epigenetic changes that may drive astrocytes toward a dysfunctional disease-associated radial glia-like (DARG) phenotype. The work is strongly research-oriented...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on programmed axon death , SARM1 , NMNAT2 , and protein design . The project focuses on understanding the mechanism of programmed axon death, an intrinsic axonal death pathway implicated in neurodegenerative disease and injury. The work will use rational protein design to create variant forms of SARM1 or hybrid reporter constructs to study activation, stability, enzyme activity, and post-translational modi...

Cardiff University is advertising a funded PhD project on unravelling the physiological drivers of sleep-dependent glymphatic flow in Alzheimer’s disease using advanced MRI . The project sits in the Cardiff School of Physics and Astronomy and is supervised by Prof Kevin Murphy . The research is part of the SleepBoost study, a £4.3m multi-centre investigation into how improving slow-wave sleep may enhance waste clearance in the brain and potentially slow or reverse Alzheimer’s disease pathology. ...