University of Oxford
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PhD in Reprogramming Human Envelope Proteins for Neuronal Genome Editing University of Oxford in United Kingdom
Degree Level
PhD
Field of study
Computer Science
Funding
Funded PhD project. The MRC CoRE-TG DPhil scholarship, if awarded, covers course fees for the duration of fee liability, a living stipend at the UKRI rate for four years, a £20,000 Research Training Support Grant, and a £1,200 travel allowance. International students are not eligible for this scholarship nomination due to UKRI limits.
Deadline
Dec 1, 2026
Country
United Kingdom
University
University of Oxford
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About this position
PhD opportunity at the University of Oxford in the Radcliffe Department of Medicine on Reprogramming Human Envelope Proteins for Neuronal Genome Editing.
This project focuses on neuronal genome editing, CRISPR RNP delivery, human endogenous retroviruses (hERVs), protein engineering, genomics, and viral vector development. The aim is to discover and engineer endogenous human envelope proteins into programmable delivery modules for selective targeting of disease-relevant neuronal cell types, with reduced off-target liver tropism and minimal immune recognition.
Training includes computational genome mining, AI-guided structural modelling, functional screening, molecular cloning, lentiviral pseudotyping, multiplexed in vivo screening, and validation in iPSC-derived neuronal models, human brain slices, mouse models, and the BEXORG ex vivo human brain model. The student will also gain experience in translational medicine, functional genomics, and innovation-oriented research.
The project is supervised by Dr Jakob H. Haldrup, Prof Steve Hyde, and Prof Carlo Rinaldi at the University of Oxford. It is a funded PhD project open to students worldwide, although the MRC CoRE-TG scholarship nomination is restricted to UK national students.
Funding, if awarded through the MRC CoRE-TG DPhil scholarship, includes course fees, a UKRI-rate stipend for four years, a £20,000 Research Training Support Grant, and a £1,200 travel allowance. The deadline shown on the listing is 1 December 2026.
To apply, register your interest via the FindAPhD listing and follow the university’s admissions process. For questions about the programme, contact [email protected].
Funding details
Funded PhD project. The MRC CoRE-TG DPhil scholarship, if awarded, covers course fees for the duration of fee liability, a living stipend at the UKRI rate for four years, a £20,000 Research Training Support Grant, and a £1,200 travel allowance. International students are not eligible for this scholarship nomination due to UKRI limits.
What's required
Applicants should be competitive and meet the admissions requirements of the relevant host department or university. The project is suitable for candidates interested in computational genome mining, protein engineering, genome editing, viral vector development, translational medicine, molecular cloning, lentiviral pseudotyping, CRISPR RNP delivery, scalable vector manufacturing, multiplexed in vivo screening, and functional genomics. The scholarship note indicates that only UK national students are eligible for the MRC CoRE-TG DPhil scholarship nomination.
How to apply
Register your interest for the project through FindAPhD. The university will respond directly, and applicants should be prepared for the departmental/university admissions process. For programme questions, contact [email protected].
More information can be found here
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