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Medical Research Council (Cambridge)

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PhD in the Macromolecular Basis of Nuclear Remodelling in Humans Medical Research Council (Cambridge) Laboratory of Molecular Biology in United Kingdom

Degree Level

PhD

Field of study

Cell Biology

Funding

Competition funded PhD project. Funding details beyond this are not specified in the post.

Deadline

Dec 8, 2026

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Country

United Kingdom

University

Medical Research Council (Cambridge)

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Keywords

Cell Biology
Molecular Biology
Biomedical Engineering
Cancer Biology
Biology
Structural Biology
Cryo-electron Microscopy
Medical Science
Cell Migration
Super-resolution Microscopy
Cytoskeleton Dynamics

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About this position

PhD opportunity in the macromolecular basis of nuclear remodelling in humans at the Medical Research Council (Cambridge), Laboratory of Molecular Biology.

This project in structural biology, cell biology, and molecular biology explores how the nucleus is reshaped by cytoskeletal filaments in human cells and how this architecture contributes to cell migration, tissue formation, immune response, and cancer progression. The lab is especially interested in the high-order organisation of the cytoskeleton at the nuclear surface and how nuclear deformability influences disease processes such as metastasis, ageing, and developmental disorders.

The PhD will combine advanced imaging and structural approaches, including electron cryo-tomography, single-particle cryo-EM, super-resolution light microscopy, correlative light and electron microscopy, and live-cell imaging. The goal is to determine the high-resolution structure of cytoskeletal filaments coating the nucleus under different mechanical conditions such as confinement, migration, and stretching, and to understand how the network reorganises in each context.

The project is described as a competition funded PhD project for students worldwide. The post does not list a stipend amount, tuition coverage, or specific eligibility thresholds, but it clearly signals a funded doctoral opening rather than a scholarship programme. No waiver is mentioned.

Supervisor: Dr Matteo Allegretti. The project page highlights support from microscopy facilities, workshops, and collaborations across LMB units.

How to apply: Register your interest on the FindAPhD project page and submit the enquiry form. The university will respond directly to applicants.

Deadline: 2026-12-08.

Funding details

Competition funded PhD project. Funding details beyond this are not specified in the post.

What's required

Applicants should be interested in structural biology and cell biology, and comfortable working with cutting-edge methods including electron cryo-tomography, single-particle cryo-EM, super-resolution light microscopy, correlative light and electron microscopy, and live-cell imaging. The project is advertised as a competition-funded PhD project for students worldwide; no specific degree, GPA, or language-test requirements are stated in the post.

How to apply

Register your interest through the FindAPhD enquiry form on the project page. The university will respond directly after you submit your details and question.

More information can be found here

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