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Marthe Walvoort

10 months ago

PhD Position in Chemical Synthesis of Complex Bacterial Glycans University of Groningen in Netherlands

Degree Level

PhD

Field of study

Biochemistry

Funding

Available

Deadline

Expired

Country flag

Country

Netherlands

University

University of Groningen

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Keywords

Biochemistry
Chemistry
Microbiology
Biology
Chemical Synthesis
Glycobiology
Carbohydrate Chemistry
Antibiotic Therapy
Structure-activity Relationship
Oligosaccharides

About this position

A fully funded 4-year PhD position is available in the Chemical Glycobiology group of Professor Marthe Walvoort at the Stratingh Institute for Chemistry, University of Groningen, as part of the NWO-Vidi project 'Healthy sugars for a healthy gut'. The Walvoort group focuses on understanding the structure-activity relationships of carbohydrates, leveraging synthetic chemistry, biochemistry, and microbiology to address fundamental and applied questions in glycobiology.

This PhD project aims to develop new chemical synthesis methods for producing a variety of bifidobacterial exopolysaccharides (EPS), which are complex carbohydrates associated with numerous health benefits, including immune modulation, anti-pathogen effects, and gut health. The project addresses the current limitations in obtaining pure EPS samples by creating modular synthetic approaches to generate EPS of different lengths and complexities, as well as novel sugar-nucleotides and glycolipids.

The synthesized EPS structures will be tested for their functional effects in intestinal model systems, laying the groundwork for establishing direct links between specific exopolysaccharides and their health-promoting properties. The project is highly interdisciplinary, involving close collaboration with another PhD project focused on enzymatic EPS production within the same NWO-Vidi framework.

The successful candidate will join a vibrant research environment at the University of Groningen, working at the interface of chemistry, biology, and health sciences. The position is fully funded for four years, offering an excellent opportunity for candidates with a strong background in chemistry, particularly those interested in synthetic chemistry, biochemistry, or microbiology. Applicants should hold a Master's degree in a relevant field and demonstrate proficiency in English. Experience with carbohydrate chemistry or interdisciplinary research is a plus.

For more information and to apply, visit the application portal linked below. This is an excellent opportunity to contribute to cutting-edge research in chemical glycobiology and to develop new tools for understanding and harnessing the health benefits of complex bacterial glycans.

Funding details

Available

What's required

Applicants should have a strong background in chemistry, preferably with experience in synthetic chemistry, biochemistry, or related fields. A Master's degree in Chemistry, Chemical Biology, Biochemistry, or a closely related discipline is required. Experience with carbohydrate chemistry, microbiology, or interdisciplinary research is advantageous. Proficiency in English is expected. No specific GPA or language test requirements are mentioned.

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Professors

Professor at University of Groningen

University Name
Country flag

Netherlands

Research Interests

Microbiology

Biochemistry

Gut Microbiota

Glycobiology

Mucosal Biology