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Université catholique de Louvain

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PhD student in intracellular persistence of Staphylococcus aureus Université Catholique de Louvain in Belgium

Degree Level

PhD

Field of study

Pharmacology

Funding

Available

Deadline

Nov 18, 2026

Country flag

Country

Belgium

University

Université catholique de Louvain

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Keywords

Pharmacology
Immunology
Microbiology
Biology
Macrophage Biology
Single-cell Analysis
Pharmacy
Host-pathogen Interaction
Omics
Monocyte Biology
Antibiotic Prescribing
Staphylococcus Aureus

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About this position

This PhD project at UCLouvain in Brussels, Belgium, focuses on the intracellular persistence of Staphylococcus aureus in the context of chronic bone and joint infections. The work is embedded in a large international consortium coordinated by the University of Reims and funded through a European collaborative program.

The doctoral researcher will investigate how clinical S. aureus isolates survive within host cells and contribute to the chronic and relapsing nature of prosthetic joint infections. The project combines host-pathogen interaction studies with antibiotic exposure experiments to better understand bacterial persistence and treatment failure.

  • Characterisation of uptake and intracellular fate of clinical S. aureus isolates in human monocytes and macrophages.
  • Analysis of infection phenotypes using strains from patients with chronic bone infections and diverse persistence-associated traits.
  • Investigation of bacterial adaptation and survival using multi-omics and single-cell approaches.
  • Development of fluorescent biosensor-based assays to study heterogeneity in bacterial responses during infection and treatment.

The project sits at the interface of microbiology, immunology, and pharmacology and offers training in cellular infection models, flow cytometry, multi-omics, and single-cell analyses. It is aimed at understanding mechanisms that drive persistence and relapse in severe bone and joint infections.

Funding details

Available

What's required

Applicants should hold a Master's degree or equivalent, preferably with distinction/cum laude, in Biology, Microbiology, Bioengineering, Biomedical or Pharmaceutical Sciences, or a related discipline. Practical experience and/or a strong interest in microbiology, mammalian cell culture, molecular biology, flow cytometry, and anti-infective pharmacology is expected. Candidates should be able to work both independently and collaboratively in a multidisciplinary and international environment, and should demonstrate curiosity, scientific rigor, and enthusiasm for experimental research. Proficiency in English is required; French is also spoken by most team members. The posting also notes 1–4 years of research experience in biological sciences.

How to apply

Send a CV, a motivation letter, and one recommendation letter by email to [email protected]. Use the subject line shown in the mailto link for the PhD position. Apply before the deadline.

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