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Université catholique de Louvain
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PhD student in intracellular persistence of Staphylococcus aureus Université Catholique de Louvain in Belgium
Degree Level
PhD
Field of study
Pharmacology
Funding
Available
Deadline
Nov 18, 2026
Country
Belgium
University
Université catholique de Louvain
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About this position
This PhD project at UCLouvain in Brussels, Belgium, focuses on the intracellular persistence of Staphylococcus aureus in the context of chronic bone and joint infections. The work is embedded in a large international consortium coordinated by the University of Reims and funded through a European collaborative program.
The doctoral researcher will investigate how clinical S. aureus isolates survive within host cells and contribute to the chronic and relapsing nature of prosthetic joint infections. The project combines host-pathogen interaction studies with antibiotic exposure experiments to better understand bacterial persistence and treatment failure.
- Characterisation of uptake and intracellular fate of clinical S. aureus isolates in human monocytes and macrophages.
- Analysis of infection phenotypes using strains from patients with chronic bone infections and diverse persistence-associated traits.
- Investigation of bacterial adaptation and survival using multi-omics and single-cell approaches.
- Development of fluorescent biosensor-based assays to study heterogeneity in bacterial responses during infection and treatment.
The project sits at the interface of microbiology, immunology, and pharmacology and offers training in cellular infection models, flow cytometry, multi-omics, and single-cell analyses. It is aimed at understanding mechanisms that drive persistence and relapse in severe bone and joint infections.
Funding details
Available
What's required
Applicants should hold a Master's degree or equivalent, preferably with distinction/cum laude, in Biology, Microbiology, Bioengineering, Biomedical or Pharmaceutical Sciences, or a related discipline. Practical experience and/or a strong interest in microbiology, mammalian cell culture, molecular biology, flow cytometry, and anti-infective pharmacology is expected. Candidates should be able to work both independently and collaboratively in a multidisciplinary and international environment, and should demonstrate curiosity, scientific rigor, and enthusiasm for experimental research. Proficiency in English is required; French is also spoken by most team members. The posting also notes 1–4 years of research experience in biological sciences.
How to apply
Send a CV, a motivation letter, and one recommendation letter by email to [email protected]. Use the subject line shown in the mailto link for the PhD position. Apply before the deadline.
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