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Royal Netherlands Academy of Arts and Sciences

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PhD student - Traumatic Brain Injury Royal Netherlands Academy of Arts and Sciences in Netherlands

Degree Level

PhD

Field of study

Computer Science

Funding

Funded by the Dutch Research Council (NWO) Open Competition; salary indicated as €3204—€4051 gross per month for a full-time appointment, plus standard employment benefits.

Deadline

Dec 1, 2026

Country flag

Country

Netherlands

University

Royal Netherlands Academy of Arts and Sciences

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Keywords

Computer Science
Biomedical Engineering
Biology
Computational Biology
Alzheimer's Disease
Neuropsychology
Neuroinflammation
Traumatic Brain Injury
Neurodegenerative Disease
Hippocampus
Ipsc
Cell Culture Techniques
Adult Neurogenesis
Statistics
Microglia
Transcriptomic

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About this position

A PhD position is available in the Neurogenesis & Neurodegeneration group at the Netherlands Institute for Neuroscience in Amsterdam, within a collaborative project involving the Swammerdam Institute of Life Sciences at the University of Amsterdam. The work is led in the Salta lab, headed by Evgenia Salta, and sits in a research environment focused on the cellular and molecular basis of brain function and dysfunction.

The project addresses how repeated mild traumatic brain injury affects the brain over the long term, with a particular focus on the hippocampus and memory-related consequences. You will investigate lasting changes in inflammatory and neurogenic processes and the cell types involved, including microglia, astrocytes and immature neurons. The aim is to identify cellular and molecular mechanisms that may help explain why repeated injury can contribute to later cognitive decline and dementia risk.

As the PhD candidate, you will work with postmortem human brain tissue from donors with a history of traumatic brain injury and use single-nucleus RNA sequencing workflows to study the cellular composition and molecular programs of the hippocampal response to injury. The project also includes sample collection and stratification, advanced computational analysis of omics data, and the development of in vitro human cell models to test candidate targets and link them to cellular phenotypes. The group combines transcriptomics with molecular and cellular approaches and uses primarily human postmortem brain tissue and iPSC reprogramming.

This is a joint research effort with the group of Carlos Fitzsimons at the University of Amsterdam, and it builds on the team’s previously published work in this area.

Funding details

Funded by the Dutch Research Council (NWO) Open Competition; salary indicated as €3204—€4051 gross per month for a full-time appointment, plus standard employment benefits.

What's required

A Master’s degree in biomedical sciences, neuroscience or a similar field is required. Strong affinity and hands-on experience with coding and omics-related computational analyses are a prerequisite, as is strong hands-on experience with single-cell transcriptomics. Experience with iPSC cell culture is a plus. Excellent spoken and written English, strong communication skills, strong organizational skills, a methodical and structured working style, rigor, accuracy, attention to detail, and a collaborative, reliable team-player attitude are expected, together with genuine passion for research, persistence, and a positive attitude toward difficult iterative problem-solving.

How to apply

Apply online via the Apply Now button before 1 December 2026. Submit a detailed CV and a motivation letter that includes your past research experience, future interests, earliest possible starting date, and the names and contact details of at least two referees. Applications are reviewed immediately until the position is filled.

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