Publisher
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Rushworth

1 year ago

PhD Studentship: Linking Myeloma Therapies, the Microbiome, and Immune Defence University of East Anglia in United Kingdom

Degree Level

PhD

Field of study

Cell Biology

Funding

4-year fully-funded studentship including tuition fees, annual stipend (£20,780 for 2025/26), and Research Training Support Grant.

Deadline

Oct 1, 2026

Country flag

Country

United Kingdom

University

University of East Anglia

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Keywords

Cell Biology
Immunology
Immunotherapy
Biology
Innate Immunity
Health Science
Human Biology
Library Science
Immune Regulation
Microbiome Research
Dna Analysis
Gut Microbiota
Multiple Myeloma
Infection Prevention
Mouse Model
Adaptive Immunity
Bioinformatic

About this position

This PhD studentship at the University of East Anglia investigates the impact of myeloma therapies on the gut microbiome and how these changes influence immune function and infection risk. Multiple myeloma affects thousands of people annually in the UK, and infections remain a significant cause of morbidity and early mortality. Recent research suggests that chemotherapy and immunotherapy can alter the gut microbiome, which is closely linked to immune regulation.

The project hypothesizes that treatment-induced changes in the microbiome directly affect immune responses and increase susceptibility to infection. The student will use both preclinical mouse models and stool samples from myeloma patients to assess microbiome alterations. In parallel, the project will explore how these changes impact immune cell populations and responses to infection. Training will be provided in in vivo techniques, including animal handling and isolation of primary human samples under ethical approval.

The student will also learn cellular biology methodologies such as DNA isolation, library preparation, sequencing, and bioinformatics for data analysis. Supervision is provided by Dr Hellmich, a clinical researcher with access to patient samples, and Prof Rushworth, an experienced supervisor with a strong track record of PhD student success. The laboratory offers a collaborative environment with regular meetings, journal clubs, and opportunities to present research at conferences. The studentship is fully funded for four years, covering tuition fees, a generous annual stipend (£20,780 for 2025/26), and a Research Training Support Grant.

Applicants should have at least a UK equivalent Bachelors (Honours) 2:1 and meet English language requirements (IELTS 6.5 overall, 6 in each category). The project provides advanced training in immunology, microbiome science, and bioinformatics, preparing graduates for future careers in biomedical research.

Funding details

4-year fully-funded studentship including tuition fees, annual stipend (£20,780 for 2025/26), and Research Training Support Grant.

What's required

Applicants must hold at least a UK equivalent Bachelors (Honours) degree with a minimum classification of 2:1. English language proficiency is required, with an IELTS score of 6.5 overall and at least 6 in each category. Experience in biological sciences, immunology, or related fields is desirable.

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Professors

Prof at University of East Anglia

University Name

University of East Anglia

Research Interests

Cell Biology

Immunology

Dna Analysis

Multiple Myeloma

Library Science