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Karl Grieshop

11 months ago

PhD Studentship: Molecular and Genomic Insights to Sexually Antagonistic Genes University of East Anglia in United Kingdom

Degree Level

PhD

Field of study

Molecular Biology

Funding

Available

Deadline

Expired

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Country

United Kingdom

University

University of East Anglia

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PhD opportunity at the University of East Anglia in functional genomics, evolutionary biology, bioinformatics, and genetic engineering . This project, supervised by Dr Karl Grieshop in the School of Biological Sciences , investigates sexually antagonistic selection in Drosophila melanogaster . The aim is to move from identifying sexually antagonistic genes to understanding what makes them special, how they affect fitness and life-history traits, and the molecular mechanisms underlying sexual con...

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Keywords

Molecular Biology
Evolutionary Biology
Biology
Aging
Sequencing Technology
Transcriptional Regulation
Pest Management
Human Health
Functional Traits
Genome Engineering
Conservation Genetics
Alternative Splicing
Sexual Conflict
Drosophila Melanogaster
Life History
Crispr/cas9
Bioinformatic

About this position

[Fully funded 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD CASE studentship with Inspiralis Limited. Includes payment of tuition fees, a stipend of £20,780 (2025/6 rate), and a Research Training Support Grant of £5,000 per annum.] This fully funded PhD studentship at the University of East Anglia investigates the molecular and genomic basis of sexually antagonistic genes, a phenomenon where genetic variants benefit one sex but harm the other, creating evolutionary tension. Supervised by Dr Karl Grieshop, the project builds on recent discoveries in Drosophila melanogaster, where consistent sets of sexually antagonistic genes have been identified.

The research aims to move beyond gene identification to understand what makes these loci unique, their impact on sex-specific fitness and life history traits, and the molecular mechanisms underlying sexual conflict and its resolution. The student will employ advanced bioinformatics, genome engineering, and sequencing technologies to identify and characterize sexually antagonistic loci across multiple studies, validate their effects using CRISPR-Cas9 allele swaps in fruit flies, and probe mechanisms such as gene regulation and alternative splicing. The project is highly interdisciplinary, offering training in computational biology, experimental genetics, molecular biology, evolutionary genetics, bioinformatics, biological statistics, and CRISPR genome engineering. Collaborative opportunities are available at Norwich Research Park, including training in long-read sequencing and single-cell transcriptomics.

The studentship is part of the Norwich Research Park Biosciences Doctoral Training Programme (NRPDTP), which provides a comprehensive professional development curriculum and a three-month professional internship placement (PIPS) for all students. The programme fosters a vibrant research community and supports career development. Funding includes full tuition, a generous stipend (£20,780 for 2025/6), and a research training support grant (£5,000 per year).

Applicants must have at least a UK equivalent Bachelors (Honours) 2:1 degree and meet English language requirements (IELTS 6.5 overall, 6 in each category). The position starts in October 2026, with interviews for shortlisted candidates scheduled for February 2026. For further details and application instructions, visit the UEA and NRPDTP websites.

Funding details

Available

What's required

Applicants must hold at least a UK equivalent Bachelors (Honours) degree with a minimum of 2:1 classification. English language proficiency is required, with an IELTS score of 6.5 overall and at least 6 in each category. The position is full-time and starts on 1 October 2026.

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Professors

Dr at University of East Anglia

University Name
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United Kingdom

Research Interests

Conservation Biology

Biostatistics

Evolutionary Biology

Sexual Dimorphism

Quantitative Genetics