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CNRS
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Post-doctoral Researcher in TMEM33, Macrophages and MASLD CNRS in France
Degree Level
Postdoc
Field of study
Immunology
Funding
Available
Deadline
Dec 29, 2026
Country
France
University
CNRS
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About this position
This postdoctoral project investigates the role of TMEM33 in the context of metabolic dysfunction-associated steatotic liver disease (MASLD), with a particular emphasis on macrophages and the broader mechanisms driving fatty liver disease. The work is part of a collaborative project with Pr. Aimin XU at The University of Hong Kong, bringing together complementary expertise around liver disease, metabolism, and translational biomedical research.
The project is grounded in strong preliminary findings showing that constitutive loss of TMEM33 protects mice against dyslipidemia, hepatic steatosis, inflammation, and obesity-induced injury. It also builds on evidence that hepatic TMEM33 expression is correlated with MASLD in obese patients. The selected researcher will contribute to a mechanistic study of how TMEM33 influences disease onset and progression, including its effects on lipid metabolism, lipid droplet biogenesis, and downstream effectors in hepatocytes.
The work combines mouse models, diet-induced disease systems, and human clinical material from a unique cohort of obese patients who underwent bariatric surgery. This cohort includes biological and clinical data, serum samples, liver biopsies, and adipose tissue, enabling the project to connect experimental findings with human disease severity and metabolic profiles. The study also explores the potential protective effect of TMEM33-targeting siRNAs in MASLD.
The host laboratory is part of the Institute of Molecular and Cellular Pharmacology of CNRS in Nice-Sophia Antipolis, in southeastern France. The environment is described as a leading biology research center with state-of-the-art equipment, offering a dynamic international setting for biomedical research.
The project aims to clarify the pathogenic role of TMEM33 in MASLD through integrated experimental and clinical approaches.
Funding details
Available
What's required
A strong background in lipid biology, immunology, and mouse experimentation is required. Candidates should have a particular interest in understanding molecular and cellular mechanisms of metabolism, liver physiology, and associated diseases.
How to apply
Apply through the official application page on the chosen public service portal. Follow the instructions on the posting and submit the required application materials before the deadline.
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Review drafts and confirm requirements with the university.