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Christoph Merten

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Postdoctoral Position in Microfluidic RNAseq-Based Screening for Optimal T-Cell Expansion Protocols EPFL in Switzerland

Degree Level

Postdoc

Field of study

Cell Biology

Funding

Available

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Country

Switzerland

University

EPFL

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Keywords

Cell Biology
Immunotherapy
Biomedical Engineering
Chemical Engineering
Medical Science
Next-generation Sequencing
Rna-seq
Microfluidic
Bioinformatic

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About this position

The Laboratory of Biomedical Microfluidics (LBMM) at EPFL is seeking a postdoctoral researcher for a highly translational project at the interface of microfluidics, genomics, and cell therapy. The work focuses on highly multiplexed RNAseq-based screening to identify optimal protocols for expanding cancer-specific autologous TILs for clinical use.

The project is embedded in the LBMM’s long-standing technology-development environment, which combines a tech development lab on the EPFL campus with a translational lab at the AGORA cancer research center. The postdoc will collaborate closely with the laboratory of George Coukos and interact with experts in microfluidics and bioinformatics.

Research activities include the optimization of microfluidic and biochemical workflows, development of miniaturized T-cell expansion assays including feeder-cell systems, preparation of NGS libraries, and analysis of sequencing data with support from a bioinformatics facility. The post is based on repurposing established microfluidic platforms and is positioned within a lab with strong biomedical and genomics expertise, as well as links to clinical partners in Europe and the US.

The environment is geared toward cutting-edge experimental work and translational technology development in biomedical microfluidics.

Funding details

Available

What's required

Applicants should have primary training in cell biology and next-generation sequencing. Hands-on experience in cell biology and NGS is expected, with good knowledge of T-cell expansion and therapy. Prior experience in droplet-microfluidics, including commercial systems such as the 10X Genomics platform, is advantageous but not absolutely required. Good communication skills and motivation for tech development are also preferred.

How to apply

Apply through the online platform only. Submit a brief cover letter, a CV with publication list in one PDF, a research statement, and contact details for three referees.

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Professors

Prof. at EPFL

University Name
Country flag

Switzerland

Research Interests

Cell Biology

Biochemistry

Next-generation Sequencing

Microfluidic

Medical Science