Northeastern University
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Postdoctoral Research Associate in Anaerobic Microbiology, Enzyme Biochemistry and Natural Products Discovery Northeastern University in United States
Degree Level
Postdoc
Field of study
Chemistry
Funding
Full-time paid postdoctoral research position with an expected hiring range of $60,315.00–$85,192.50. Northeastern University offers a comprehensive benefits package for eligible employees, including medical, vision, dental, paid time off, tuition assistance, wellness and life benefits, retirement, and commuting and transportation benefits.
Country
United States
University
Northeastern University
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About this position
The Woolston Lab at Northeastern University is seeking a postdoctoral researcher for an NIH-funded program exploring the biosynthetic potential of Clostridial bacteria, an important but comparatively understudied source of bioactive compounds and unusual enzymes.
The research combines anaerobic microbiology, enzyme biochemistry, and natural products discovery. One direction investigates cobalamin-dependent radical S-adenosylmethionine enzymes fused to non-ribosomal peptide synthetase adenylation domains. These enzymes may catalyze stereoselective carbon-backbone methylation reactions that have not previously been described in non-ribosomal peptide synthetase biochemistry.
A complementary direction seeks novel antimicrobials from cellulolytic Clostridia. The project uses heterologous expression of biosynthetic gene clusters in a newly developed Clostridial chassis strain, alongside elicitor screening to activate cryptic pathways in native producers.
The postdoctoral researcher will work closely with Professor Woolston and an interdisciplinary team of graduate students and undergraduate researchers. Activities include independent experimental planning, assay development, bacterial genetics, cultivation under strictly anaerobic conditions, enzyme characterization, genome mining, biosynthetic gene cluster analysis, data interpretation, and preparation of scholarly research materials.
The Woolston Lab emphasizes open scientific exchange, mentorship, independent research, and collaborative scientific development. The researcher will also contribute to mentoring junior lab members and communicate findings through group meetings, conferences, publications, presentations, and reports to the funding agency.
Funding details
Full-time paid postdoctoral research position with an expected hiring range of $60,315.00–$85,192.50. Northeastern University offers a comprehensive benefits package for eligible employees, including medical, vision, dental, paid time off, tuition assistance, wellness and life benefits, retirement, and commuting and transportation benefits.
What's required
PhD in microbiology, biochemistry, chemical engineering, or a related field; a demonstrated publication record in peer-reviewed journals; experience in natural products biosynthesis or purification and functional characterization of oxygen-sensitive enzymes, with expertise in both areas especially competitive; experience with bacterial genetics workflows including cloning, genome editing, CRISPR-based tools, and transposon mutagenesis; anaerobic microbiology experience; bioinformatics skills in genome mining, biosynthetic gene cluster analysis, sequence alignment, and annotation; strong quantitative and statistical analysis skills; rigorous scientific documentation; excellent written and oral communication; ability or potential to mentor undergraduate and graduate researchers; and ability to work independently while collaborating effectively in a team.
How to apply
Apply through the Northeastern University Workday job portal using the direct posting link. Submit a resume, the required document listed in the advertisement.
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Prepare your application
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ApplyKite TwinLearns as you applyMake your next move.
Prepare your application
Review drafts and confirm requirements with the university.