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Karolinska Institutet
6 days ago
Postdoctoral Researcher in DNA nanostructures for cell targeting Karolinska Institutet in Sweden
Degree Level
Postdoc
Field of study
Cell Biology
Funding
Available
Deadline
Nov 25, 2026
Country
Sweden
University
Karolinska Institutet
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About this position
This postdoctoral project is based at the Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet and within a SciLifeLab environment. The group works at the interface of DNA nanotechnology, cell biology and high-throughput sequencing, developing self-assembled DNA nanostructures and a directed-evolution style selection platform to identify carriers that are preferentially taken up by specific cell types.
The position builds on a recently established workflow in which libraries of DNA nanostructures are folded, incubated with cells, recovered from lysates and sequenced over repeated rounds. The aim is to move beyond proof of concept toward cell-specific delivery of therapeutic payloads. The postdoctoral researcher will extend the platform to disease-relevant cell models and help characterise selected nanostructures in detail.
The work includes design, assembly and purification of DNA nanostructures and nanostructure libraries; selection experiments in mammalian cells; and detailed analysis of internalisation, localisation and uptake routes using imaging and cytometry. The researcher will also functionalise structures with targeting groups and therapeutic payloads, and evaluate how the selected constructs perform in cells.
The project makes use of advanced infrastructure at Karolinska Institutet and SciLifeLab, including state-of-the-art imaging, flow cytometry and sequencing capabilities. The environment is described as open, collaborative and international, with opportunities to develop independence, contribute to manuscripts and conferences, and participate in supervision of students. The broader department conducts research and teaching in immunology, infection biology, cell biology and cancer, providing a strong medical and interdisciplinary setting for the project.
Funding details
Available
What's required
A PhD in cell biology, molecular biology, biochemistry, biomedicine, nanotechnology or a related field is required, or an equivalent foreign degree. Candidates should have documented experience of mammalian cell culture and cell-based assays, with publications in peer-reviewed journals, plus hands-on experience with confocal microscopy and/or flow cytometry including independent sample preparation and quantitative analysis. Experience with nucleic acids and standard molecular biology techniques such as PCR, enzymatic DNA modification and gel electrophoresis is required. Applicants should be able to plan, carry out and report experimental work independently, document it rigorously, and have very good spoken and written English. Recent PhD completion is considered an advantage.
How to apply
Submit the application through the Varbi recruitment system. Include a PhD certificate, a complete CV with thesis details and academic history, a complete publication list, and a one-page summary of current work. Prepare the documents in English or Swedish.
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