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University of Orléans
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Postdoctoral Researcher in Formulation of a New Broad-Spectrum Lipophilic Antiviral Université Orléans in France
Degree Level
Postdoc
Field of study
Chemistry
Funding
Available
Deadline
Nov 12, 2026
Country
France
University
University of Orléans
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About this position
This postdoctoral project at Université d'Orléans focuses on the formulation and delivery of LAVR-289, a broad-spectrum lipophilic antiviral discovered by the team and already supported by patent and publication evidence. The goal is to transform this molecule into suitable dosage forms for cutaneous delivery and, where relevant, parental intravenous delivery, with a strong emphasis on topical administration.
The research is centered on developing innovative pharmaceutical systems such as crèmes, pommades, patches, Emulgel, Oléogel, and TheDES, as well as structured systems including microspheres and biodégradable, biocompatible polymeric films. These formulations are intended to provide controlled and predetermined release of the active ingredient while maintaining sufficient drug loading to support antiviral activity.
The project builds on promising preclinical work showing strong activity of LAVR-289 against several DNA viruses, including cytomegalovirus, varicella zoster virus, adenoviruses, and poxviruses. It also responds to prior in vivo findings from NIH studies indicating topical efficacy against zoster and HSV-1, making topical formulation development a particularly important part of the research direction.
The successful candidate will contribute to the development of bioanalytical HPLC methods to evaluate cutaneous permeability and support formulation characterization. The work is carried out in partnership with the Pharmacie Centrale des Armées, a French military pharmaceutical establishment, placing the project in a translational environment that links antiviral discovery, pharmaceutical formulation, and preclinical development.
The project is clearly positioned around innovative drug-delivery systems for a novel antiviral candidate with broad-spectrum potential.
Funding details
Available
How to apply
Apply via the provided Choisir le service public job portal link. Review the advert and submit the application before the deadline.
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