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CNRS
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Postdoctoral Researcher in Optics: Measurement, Instrument Development and Simulation CNRS in France
Degree Level
Postdoc
Field of study
Chemistry
Funding
Available
Deadline
Nov 19, 2026
Country
France
University
CNRS
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About this position
This postdoctoral position at CNRS is part of the MALDI3.0 project, a collaborative effort in Lille bringing together PRISM Inserm U1192, Centre Oscar Lambret, and PhLAM CNRS UMR 8523. The project aims to improve the sensitivity of tissue-protein imaging by adding an innovative infrared post-desolvation step to a MALDI imaging workflow.
The researcher will work on the transport and shaping of an infrared laser beam used to intercept the expanding MALDI plume. The goal is to optimize how the IR beam reaches the commercial MALDI spectrometer and how it interacts with the desorption/ionization process triggered by the first UV laser. The work combines optical design, instrument integration, simulation, and experimental measurements.
Key tasks include defining the opto-mechanical elements needed to deliver the IR beam into the correct region of the spectrometer, shaping the beam profile, reducing its width, and potentially enabling adjustable focusing in the MALDI plume formation zone. The researcher will also optimize the timing between the UV and IR lasers and evaluate the resulting performance in MALDI-MSI on biological tissues, with attention to reproducibility and temporal stability.
The project uses both modeling and laboratory experimentation. Optical solutions will be tested with CODE V and/or Zemax OpticStudio, while experimental work will characterize the transverse beam profile in the infrared and track beam properties along propagation to avoid hot spots. The research sits within a broader effort to develop a dual-laser source for more sensitive tissue protein imaging.
Funding details
Available
How to apply
Apply via the posted government recruitment page using the application link provided. Prepare and submit the required materials through that portal before the deadline.
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