Publisher
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Montana State University

Postdoctoral Researcher in Structural Biology and Cryo-EM of Bacterial Immune Systems at Montana State University Montana State University in United States

Degree Level

Postdoc

Field of study

Biochemistry

Funding

Salary is commensurate with experience, education, and qualifications. Full-time research professional postdoctoral appointment with benefits eligibility.

Deadline

Expired

Country flag

Country

United States

University

Montana State University

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Keywords

Biochemistry
Molecular Biology
Evolutionary Biology
Chemistry
Biomedical Engineering
Biology
Structural Biology
Cryo-electron Microscopy
Medical Science
Bioinformatic
Physics

About this position

Montana State University is advertising a Postdoctoral Researcher position in the Wiedenheft Lab, focused on structural biology, cryo-EM, and the molecular mechanisms of bacterial immune systems that defend against phage infection.

The project centers on CRISPR-Cas complexes, Defense-associated Reverse Transcriptases (DRTs), Retrons, and other newly discovered anti-phage defense systems. The successful candidate will use single-particle cryo-electron microscopy to determine high-resolution structures and connect structural findings with biochemical, genetic, and evolutionary analyses.

The postdoc will have access to a 200 keV Thermo Fisher Talos Arctica in the Cryo-EM Facility, along with complementary biochemistry, molecular biology, and bioinformatics resources. Responsibilities include protein complex preparation and purification, cryo-EM data collection and processing, workflow optimization, collaboration with computational and molecular biology teams, manuscript preparation, and mentoring trainees.

Eligibility highlights: a Ph.D. in Structural Biology, Biochemistry, Biophysics, Microbiology, Molecular Biology, or a related field; hands-on cryo-EM experience; strong protein expression/purification skills; productivity through publications or preprints; and strong communication and teamwork skills. Preferred experience includes Talos Arctica operation, membrane proteins, lipid nanodiscs, and evolutionary genomics of bacterial immune systems.

Funding: salary is commensurate with experience, education, and qualifications, and the appointment is benefits eligible. The posting also notes that the position is not eligible for new sponsorship.

Application window: screening begins on 2026-06-23, and applications will be accepted until an adequate applicant pool is established.

Funding details

Salary is commensurate with experience, education, and qualifications. Full-time research professional postdoctoral appointment with benefits eligibility.

What's required

Ph.D. in Structural Biology, Biochemistry, Biophysics, Microbiology, Molecular Biology, or a related field. Hands-on experience with single-particle cryo-EM, including data collection, processing, and interpretation, is required. Applicants should have a strong background in protein expression, purification, and biochemical characterization, demonstrated ability to troubleshoot and optimize workflows, evidence of productivity through publications or preprints, and excellent communication, teamwork, and organizational skills. Preferred experience includes cryo-EM at 200 keV or Talos Arctica operation, work on proteins involved in immunity, membrane protein purification, lipid nanodiscs or detergent-solubilized systems, computational phylogenetics or evolutionary genomics of bacterial immune systems, and mentoring or supervising trainees. This position is not eligible for new sponsorship.

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Professors

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University Name
Country flag

United States

Research Interests

Cell Biology

Biochemistry

Next-generation Sequencing

Molecular Biology

Genome Editing