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Alessio Ciulli

2 months ago

Postdoctoral Scientist in Structural Biology and Molecular Biophysics for PhosTACs University of Dundee in United Kingdom

Degree Level

Postdoc

Field of study

Chemistry

Funding

Fixed-term postdoctoral salaried position at the University of Dundee; salary £37,174 - £45,413 per annum (Grade 7).

Deadline

Aug 31, 2026

Country flag

Country

United Kingdom

University

University of Dundee

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Keywords

Chemistry
Biomedical Engineering
Biophysics
Biology
Crystallography
Structural Biology
Cryo-electron Microscopy
Chemical Biology
Medical Science
Nmr Spectroscopy
Protein-protein Interaction
Physics

About this position

University of Dundee is advertising a Postdoctoral Scientist position (UOD2333) in the Centre for Targeted Protein Degradation within the Faculty of Life Sciences.

The project sits in an interdisciplinary, cross-institutional collaboration focused on developing Phosphatase Targeting Chimeras (PhosTACs). The successful candidate will work in the CeTPD laboratories on structural biology and molecular biophysics, characterising protein-ligand interactions and protein-protein complexes to understand binding modes, structure-activity relationships (SAR), and to guide improved molecule design.

Key techniques and responsibilities include X-ray crystallography, cryo-EM, NMR spectroscopy, SPR, ITC, fluorescence-based assays, protein expression and purification, construct design, and structure-guided design recommendations. This is described as a more independent role than a standard support post, with increasing ownership of structural enablement and a leading role in the collaboration’s design workstream.

Applicants should hold a PhD in structural biology, biophysics, biochemistry, chemical/molecular biology, or a related discipline. Strong experience in structural biology and biophysics, especially structure-based drug design, is expected. Experience with protein structure determination and biophysical binding assays is strongly desired, along with strong communication, time management, teamwork, and independent working skills.

Funding/salary: fixed-term postdoctoral employment with a salary of £37,174 - £45,413 per annum (Grade 7).

Deadline: Monday, 31 August 2026, 23:59.

How to apply: Use the external candidate application link on the University of Dundee jobs page. Internal candidates should apply via OneUniversity. For further information, contact Professor Alessio Ciulli at [email protected].

Funding details

Fixed-term postdoctoral salaried position at the University of Dundee; salary £37,174 - £45,413 per annum (Grade 7).

What's required

A PhD in structural biology, biophysics, biochemistry, chemical/molecular biology or a related discipline is required. Strong experience in structural biology and biophysics with emphasis on structure-based drug design is expected, along with a strong background in protein structure determination by X-ray crystallography, cryo-EM and/or NMR spectroscopy. Experience with biophysical techniques and assays for protein-ligand binding and protein-protein interactions is strongly desired. Applicants should have strong interpersonal, time management and communication skills, an open and collaborative approach, and the ability to work independently in a diverse cross-institutional team.

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Professors

Professor

University Name
Country flag

United Kingdom

Research Interests

Biochemistry

Biochemical Engineering

Chemical Biology

Ligand Chemistry

Proteostasis