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Nicolas Bremond

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Postdoctorant (H/F) in NF1 microenvironment microfluidics and high-resolution imaging Ecole supérieure de physique et de chimie industrielles de la Ville de Paris in France

Degree Level

Postdoc

Field of study

Computer Science

Funding

Available

Country flag

Country

France

University

ESPCI Paris - PSL (Ecole Supérieure de Physique et de Chimie Industrielles de la ville de Paris)

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Keywords

Computer Science
Biomedical Engineering
Chemical Engineering
Materials Science
Medical Imaging
Biology
Artificial Intelligence
Medical Science
Extracellular Matrix Biology
High-resolution Imaging
Drug Screening
Microfluidic

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About this position

This postdoctoral project at ESPCI Paris is part of a consortium focused on neurofibromatosis type 1 (NF1), a cancer-predisposition disease that causes nerve sheath tumors. The work brings together NF1 biologists, biomedical imaging and computing experts, and soft-matter/microfluidics researchers to build experimental tools for studying the disease microenvironment.

The project aims to develop a microfluidic microsystem that reproduces the peripheral nervous system microenvironment and supports co-culture of neurons with surrounding cells such as Schwann cells and fibroblasts. These microsystems will incorporate extracellular-matrix-mimicking hydrogels to enable controlled cell interactions around axons embedded in a matrix-like environment.

A major research goal is to obtain high-resolution imaging of cell morphology under different conditions so that AI-based models can be trained for automated analysis of cell interactions in their microenvironment. The position therefore combines device development, cell culture, imaging, and computational analysis in a biomedical context.

The second part of the project builds on a high-throughput compartmentalized cell-culture methodology already developed in the laboratory. In this system, cells are trapped inside capsule-like compartments with a liquid core and hydrogel membrane, produced by high-speed coextrusion in air.

The postdoctoral researcher will work on two main developments: a drug-screening method based on encapsulated cells, and tuning hydrogel porosity to support neuronal axon growth. This part of the work is carried out in collaboration with a PhD student developing chemical strategies to control hydrogel porosity. The project is embedded in a consortium involving ESPCI Paris, the Institut Mondor de recherche biomédicale, and the CEA imaging group.

Funding details

Available

How to apply

Apply through the official job advert on the French public service portal. Follow the application link provided in the posting and submit the requested materials through that portal.

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Professors

Professor at Ecole supérieure de physique et de chimie industrielles de la Ville de Paris

University Name
Country flag

France

Research Interests

Medical Imaging

Artificial Intelligence

Biology

Computer Science

High-resolution Imaging