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FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências

Recruitment of a PhD Scientific Researcher (Initial Stage Researcher) #CC1753_02 FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências in Portugal

Degree Level

PhD

Field of study

Cell Biology

Funding

Available

Deadline

Nov 20, 2026

Country flag

Country

Portugal

University

FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências

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Keywords

Cell Biology
Molecular Biology
Biology
Microscopy
Developmental Biology
Neuropsychology
Quantitative Imaging
Zebrafish Biology
Genetic

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About this position

This opening is for a PhD Scientific Researcher in the Initial Stage Researcher category within the project Beating4aleft-heart: Ions and cilia motility regulation at the base of heart sidedness (Ref. LCF/PR/HR26/53000026). The project focuses on how ionic regulation and cilia motility contribute to the mechanisms that establish heart sidedness and left-right body asymmetry.

The successful researcher will contribute to a work plan centred on two linked aims. First, the project examines a flow homeostasis system driven by ionic regulation of cilia motility, including experiments on V-ATPase, CFTR, proton pumping, pH regulation, and the dual role of CFTR as both a bicarbonate channel and a mechanosensory channel involved in LRO volume control. Second, the researcher will investigate mechanosensitive channels in the left-right organizer and define hierarchical relationships among the proteins involved in symmetry breaking.

Specific research tasks include testing whether CFTR functions as a left-right mechanosensor, examining whether Pericentrin forms a complex with Pkd2 and Piezo2a, carrying out knock-down screens for mechanosensitive channels, and genetically characterizing the hierarchy and function of the relevant players. The work is embedded in developmental and molecular cell biology approaches, with strong use of zebrafish-based experimental systems, quantitative imaging, and mechanistic analysis of cilia-associated processes.

The position is hosted at cE3c – Centre for Ecology, Evolution and Environmental Changes in Campo Grande, Lisbon, within the broader FCiências.ID research environment.

Funding details

Available

What's required

Applicants must hold a doctoral degree in Neuroscience, Developmental Biology, Cell Biology, Molecular Biology, Genetics or a similar area, and the PhD must have been awarded less than 3 years ago. Required experience includes laboratory animal sciences, participation in scientific congresses with posters or oral communications, and at least 3 peer-reviewed scientific articles. Strong background in molecular and cellular biology is required, along with experience in confocal microscopy and quantitative imaging (sample mounting, image acquisition, processing, analysis, and live imaging), investigation of left-right asymmetry or embryonic symmetry breaking, generation of genetically modified/transgenic zebrafish lines, and molecular approaches to gene regulation, signaling pathways, ionic channels, or mechanosensitive mechanisms. Preferential requirements include team research skills, independent experimental design, problem solving, adaptation to new strategies, strong scientific communication skills in English, previous experience in developmental biology and/or embryonic development, and zebrafish micromanipulation and embryonic research experience. Foreign degrees require Portuguese recognition for contract signature.

How to apply

Prepare the required documents in Portuguese or English, including a detailed CV, motivation letter, up to five relevant publications, proof of the PhD degree, and any optional supporting documents. Submit the application by email to [email protected]. Ensure the submission includes the required personal information and keep proof of the sent message.

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