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Adam Patterson

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Associate Professor

University of Auckland

New Zealand

Research Interests

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Professors in New Zealand Professors in Biochemistry Biochemistry professors in New Zealand

About

Adam Patterson is an Associate Professor at the University of Auckland, New Zealand. His research primarily focuses on cancer therapeutics, particularly the design and evaluation of hypoxia-activated prodrugs and their application in targeted cancer treatments. Recent publications highlight his work on enzyme/prodrug combinations, structural evaluations of nitroreductases, and the mechanisms of tumor hypoxia in cancer immunotherapy.

Recent Grants

Grant: Open

Discovery and development of global immuno-oncology therapeutics

Open Date: 2025-10-01

Close Date: 2028-09-30

Grant: Close

Collaborative biomedical research programme with leading Chinese institutions

Open Date: 2020-06-30

Close Date: 2026-06-30

Articles (11)

Year:

2024

Year:

2022

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2020

Year:

2020

Collaborators (8)

Stephen Liu

Associate Professor

Georgetown University School of Medicine

UNITED STATES

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Amir Ashoorzadeh

Senior Research Fellow

University of Auckland

NEW ZEALAND

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Iman Kavianinia

Senior Research Fellow

University of Auckland

NEW ZEALAND

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David Ackerley

Professor and Programme Director, Biotechnology

Victoria University of Wellington

NEW ZEALAND

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Gintautas Bagdziunas

Senior researcher

Vilnius University

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Michael P. Hay

University of Auckland

NEW ZEALAND

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ROBERT ANDERSON

Professor

University of Auckland

NEW ZEALAND

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Jan Theys

University of Maastricht

NETHERLANDS

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Adam Patterson

Research Interests

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About

Recent Grants

Articles (11)

Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623

Interrogation of the Structure–Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications

Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours.

Tarloxotinib Is a Hypoxia-Activated Pan-HER Kinase Inhibitor Active Against a Broad Range of HER-Family Oncogenes

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506

Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3

Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents

Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy

Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug

Alanine scan-guided synthesis and biological evaluation of analogues of culicinin D, a potent anticancer peptaibol

Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity

Collaborators (8)

Stephen Liu

Amir Ashoorzadeh

Iman Kavianinia

David Ackerley

Gintautas Bagdziunas

Michael P. Hay

ROBERT ANDERSON

Jan Theys

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