David Ackerley

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Professor and Programme Director, Biotechnology

Victoria University of Wellington

New Zealand

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David Ackerley is a Professor and Programme Director in Biotechnology at Victoria University of Wellington, New Zealand. His research encompasses areas such as the heterologous expression of epoxomicin, CRISPR screening for genetic regulation, and the structural evaluation of engineered nitroreductases. Recent publications include studies on bromotyrosine compounds, gene-directed prodrug therapy mechanisms, and high-throughput modifications of nonribosomal peptides.

Recent Grants

Grant: Close

Using the tumour-homing properties of CAR T-cells to facilitate targeted chemotherapy of solid tumours

Open Date: 2020-01-01

Close Date: 2023-01-01

Grant: Close

Molecular contingency on a massive scale: how entirely new antibiotic resistance genes evolve

Open Date: 2020-01-01

Close Date: 2023-01-01

Grant: Close

Enzyme-based biosensors for smarter winemaking

Open Date: 2018-10-01

Close Date: 2021-09-30

Articles (20)

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2025

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2022

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2022

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2022

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2022

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2021

Collaborators (12)

Rob Keyzers

Associate Professor

Victoria University of Wellington

NEW ZEALAND

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Jeff Mumm

Associate Professor

Johns Hopkins University School of Medicine

UNITED STATES

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Michael J. Parsons

University of California

UNITED STATES

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Gregory Challis

Monash Warwick Alliance Professor of Sustainable Chemistry (Chemical and Synthetic Biology)

MONASH UNIVERSITY

AUSTRALIA

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Andrew Marshall

Victoria University of Wellington

NEW ZEALAND

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Jonathan Astin

Senior Lecturer

University of Auckland

NEW ZEALAND

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Amir Ashoorzadeh

University of Auckland

NEW ZEALAND

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Regan Anderson

Victoria University of Wellington

NEW ZEALAND

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Anne L. Calof

University of California, Irvine

UNITED STATES

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Benjamin J. Compton

Victoria University of Wellington

NEW ZEALAND

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Adam Patterson

Associate Professor

University of Auckland

NEW ZEALAND

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Jan Theys

University of Maastricht

NETHERLANDS

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David Ackerley

Research Interests

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About

Recent Grants

Articles (20)

Purpuramine R, a New Bromotyrosine Isolated from Pseudoceratina cf. verrucosa Collected in the Kingdom of Tonga

Purpuramine R, a New Bromotyrosine Isolated from Pseudoceratina cf. verrucosa Collected in the Kingdom of Tonga

Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides

Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623

Heterologous Expression of Epoxomicin in Escherichia coli

Heterologous Expression of Epoxomicin in Escherichia coli

A large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration

Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623

The Catalysis Mechanism of E. coli Nitroreductase A, a Candidate for Gene-Directed Prodrug Therapy: Potentiometric and Substrate Specificity Studies

The Catalysis Mechanism of E. coli Nitroreductase A, a Candidate for Gene-Directed Prodrug Therapy: Potentiometric and Substrate Specificity Studies

mRNA vaccine against malaria tailored for liver-resident memory T cells

An inducible model of chronic hyperglycemia

The Crystal Structure of Engineered Nitroreductase NTR 2.0 and Impact of F70A and F108Y Substitutions on Substrate Specificity

Development of a compartmentalised self-replication protocol for selection of superior blunt-end DNA ligases

Directed Evolution of the BpsA Carrier Protein Domain for Recognition by Non-cognate 4′-Phosphopantetheinyl Transferases to Enable Inhibitor Screening

S-32-02 Characterization and toxicology of azo dye metabolites

A New Transgenic Line for Rapid and Complete Neutrophil Ablation

Interrogation of the Structure–Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications

NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation

Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours.

Collaborators (12)

Rob Keyzers

Jeff Mumm

Michael J. Parsons

Gregory Challis

Andrew Marshall

Jonathan Astin

Amir Ashoorzadeh

Regan Anderson

Anne L. Calof

Benjamin J. Compton

Adam Patterson

Jan Theys

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