Adam Sharples
Professor (Full) of Molecular Physiology and Epigenetics
NorwayResearch Interests
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About
Adam Sharples is a Professor of Molecular Physiology and Epigenetics at the Norwegian School of Sport Sciences. His research focuses on the molecular mechanisms of exercise adaptation in human skeletal muscle, including subjects such as muscle epigenetics and proteomics. Recent articles highlight his work on exercise-induced changes in muscle memory and gene expression, as well as the integration of multi-omics approaches to understand muscle physiology more deeply. He is based in Norway.
Articles (10)
Year:
2025
Year:
2025
Year:
2025
Year:
2025
Year:
2024
Year:
2023
We identify novel epigenetically regulated genes associated with train-low sleep-low paradigms. Exercise under low-carbohydrate (CHO) energy-balance (high-fat) conditions elicited a more prominent DNA hypomethylation signature 30 minutes postexercise compared with low-CHO energy-deficit (low-fat) conditions. This was enriched within IL6-JAK-STAT signaling, metabolic processes, p53, cell cycle, oxidative phosphorylation, and fatty acid metabolism. Histone deacetylase (HDAC) family members 2, 4, 10, and 11 demonstrated hypomethylation, with HDAC2 and HDAC11 possessing alternative regulation of gene expression in energy balance versus deficit conditions.
Year:
2023
Year:
2023
Year:
2023
Year:
2023
Collaborators (16)
Thomas Michael Doering
Senior Lecturer
Central Queensland University
Jørn Helge
Københavns Universitet
Kevin Ashton
Bond University
ROBERTO BOTTINELLI
Full Professor
Università degli Studi di Pavia
Sarah Voisin
-
Miina Ollikainen
University of Helsinki
Rachelle Irwin
Lecturer in Genomic Medicine
University of Ulster
Atul Deshmukh
Københavns Universitet
Vincent Dalbo
Central Queensland University
Ola Hansson
Lund University
Jostein Hallén
Professor at The Norwegian School of Sport Sciences
Norwegian School of Sport Sciences
John Max Michel
Auburn University
José L. Areta
-
May Grydeland
Associate Professor
Norwegian School of Sport Sciences
Päivi Piirilä
University of Helsinki
Michael D. Roberts
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