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Agnieszka Basta-Kaim

Institute of Pharmacology

Poland

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Research Interests

Systems Neuroscience

30%

Pharmacology

60%

Microglia

50%

Neuroprotection

40%

Neuroinflammation

30%

Inflammatory Biology

30%

Neuropharmacology

30%

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Recent Grants

Grant: Close

Modulacja procesów zapalnych z zastosowaniem nowych agonistów receptorów formylowych ALX/FPR2 jako nowa strategia terapeutyczna depresji.

Open Date: 2018-05-24

Close Date: 2021-05-23

Grant: Close

Określenie roli białek neuronalno-mikoglejowych CX3CL1-CX3CR1 oraz CD200-CD200R w molekularnych mechanizmach działania leków przeciwpsychotycznych w neurorozwojowych modelach schizofrenii: badania in vivo i in vitro.

Open Date: 2016-07-20

Close Date: 2019-07-19

Grant: Close

Rola chemokin w patogenezie depresji i molekularnym mechanizmie działania leków przeciwdepresyjnych.

Open Date: 2014-04-07

Close Date: 2017-04-06

Articles17

Hydrogen Sulfide (H<sub>2</sub>S)-Donating Formyl Peptide Receptor 2 (FPR2) Agonists: Design, Synthesis, and Biological Evaluation in Primary Mouse Microglia Culture

Article Link

Year:

2025

Multilayered Nanocarriers as a New Strategy for Delivering Drugs with Protective and Anti-inflammatory Potential: Studies in Hippocampal Organotypic Cultures Subjected to Experimental Ischemia

Article Link

Year:

2025

Mechanobiology of Dental Pulp Cells

Article Link

Year:

2024

Prenatal Immune Challenge Differentiates the Effect of Aripiprazole and Risperidone on CD200–CD200R and CX3CL1–CX3CR1 Dyads and Microglial Polarization: A Study in Organotypic Cortical Cultures

Article Link

Year:

2024

Integrated Profiling Identifies Long-Term Molecular Consequences of Prenatal Dexamethasone Treatment in the Rat Brain—Potential Triggers of Depressive Phenotype and Cognitive Impairment

Article Link

Year:

2024

Contribution of changes in the orexin system and energy sensors in the brain in depressive disorder - a study in an animal model

Article Link

Year:

2024

Insights into the Potential Impact of Quetiapine on the Microglial Trajectory and Inflammatory Response in Organotypic Cortical Cultures Derived from Rat Offspring

Article Link

Year:

2023

Oxygen-Glucose Deprivation in Organotypic Hippocampal Cultures Leads to Cytoskeleton Rearrangement and Immune Activation: Link to the Potential Pathomechanism of Ischaemic Stroke

Article Link

Year:

2023

The Vitamin D Receptor as a Potential Target for the Treatment of Age-Related Neurodegenerative Diseases Such as Alzheimer’s and Parkinson’s Diseases: A Narrative Review

Article Link

Year:

2023

The Effects of Prenatal Dexamethasone Exposure on Brain Metabolic Homeostasis in Adulthood: Implications for Depression

Article Link

Year:

2023

Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study of Organotypic Hippocampal Cultures

Article Link

Year:

2023

Vitamin D3 and Ischemic Stroke: A Narrative Review

Article Link

Year:

2022

Quetiapine Ameliorates MIA-Induced Impairment of Sensorimotor Gating: Focus on Neuron-Microglia Communication and the Inflammatory Response in the Frontal Cortex of Adult Offspring of Wistar Rats

Article Link

Year:

2022

Antioxidant and Neuroprotective Activity of Vitamin E Homologues: In Vitro Study

Article Link

Year:

2022

Adverse Childhood Experiences Predict the Phenome of Affective Disorders and These Effects Are Mediated by Staging, Neuroimmunotoxic and Growth Factor Profiles

Article Link

Year:

2022

Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways

Article Link

Year:

2021

The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Exhibits Anti-Inflammatory Activity in LPS-Stimulated Organotypic Hippocampal Cultures

Article Link

Year:

2021

Collaborators9

Magdalena Regulska

POLAND

Marcello Leopoldo

Full professor

University of Bari Aldo Moro

ITALY

Jan Detka

Institute of Pharmacology

POLAND

Julita Wesołowska

Research and teaching assistant

Jagiellonian University

POLAND

Enza Lacivita

Associate Professor

University of Bari Aldo Moro

ITALY

Andrzej Żądło

Jagiellonian University

POLAND

Danuta Jantas

assistant professor

Institute of Pharmacology

POLAND

Andrzej Kubiak

Jagiellonian University

POLAND

Katarzyna Curzytek

Institute of Pharmacology

POLAND

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