Enza Lacivita

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Associate Professor

University of Bari Aldo Moro

Italy

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About

Enza Lacivita is an Associate Professor at Università degli Studi di Bari Aldo Moro in Italy. Her research primarily focuses on the pharmacological effects and therapeutic potentials of serotonin receptors and formyl peptide receptors, as evidenced by her recent publications. Professor Lacivita is also involved in the exploration of allosteric modulators and the modulation of neuronal morphology, contributing significantly to the fields of medicinal chemistry and neuropharmacology.

Recent Grants

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Identification of a molecular scaffold for the development of a PET tracer for purinergic P2X7 receptor for molecular imaging of neuroinflammation in PD

Open Date: 2023-03-01

Close Date: 2024-09-01

Grant: Close

Promoting resolution of inflammation as an innovative therapeutic strategy for central nervous system disorders characterized by neuroinflammation

Open Date: 2022-01-01

Close Date: 2023-12-01

Grant: Close

REWIND: Reverting stem cellular sEnescence With antiagIng Natural compounDs

Open Date: 2022-01-01

Close Date: 2024-01-01

Grant: Close

Drug development of pro-resolving ALX/FPR2 agonists for Alzheimer's Disease

Open Date: 2018-06-01

Close Date: 2020-06-01

Grant: Close

Fondo di FInanaziamento della Ricerca di Base

Open Date: 2017-10-01

Close Date:

Articles (16)

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2025

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2024

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2024

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2024

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2022

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2022

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2021

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2021

Collaborators (8)

Magdalena Regulska

POLAND

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Marcello Leopoldo

Full professor

University of Bari Aldo Moro

ITALY

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Carla Perrone-Capano

Full professor of Physiology

University of Naples Federico II

ITALY

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Carmen Abate

Associate Professor

University of Bari Aldo Moro

ITALY

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Agnieszka Basta-Kaim

Institute of Pharmacology

POLAND

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Marianna CRISPINO

Associate Professor

University of Naples Federico II

ITALY

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Katarzyna Curzytek

Institute of Pharmacology

POLAND

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Floriana Volpicelli

University of Naples Federico II

ITALY

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Enza Lacivita

Research Interests

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About

Recent Grants

Articles (16)

Hydrogen Sulfide (H<sub>2</sub>S)-Donating Formyl Peptide Receptor 2 (FPR2) Agonists: Design, Synthesis, and Biological Evaluation in Primary Mouse Microglia Culture

Multitarget-Directed Ligands Hitting Serotonin Receptors: A Medicinal Chemistry Survey

Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey

Modulation of neuronal morphology by antipsychotic drug: Involvement of serotonin receptor 7

Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists

Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study of Organotypic Hippocampal Cultures

Stimulation of Formyl Peptide Receptor-2 by the New Agonist CMC23 Protects against Endotoxin-Induced Neuroinflammatory Response: A Study in Organotypic Hippocampal Cultures

The Formyl Peptide Receptor 2 as a Target For Promotion of Resolution of Inflammation

5-HT7 Receptors Regulate Excitatory-Inhibitory Balance in Mouse Spinal Cord Dorsal Horn

Design, Synthesis, and Characterization of a Novel Fluoroprobe for Live Human Islet Cell Imaging of Serotonin 5‐HT1A Receptor

Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders

In Vitro and In Silico Analysis of the Residence Time of Serotonin 5-HT7 Receptor Ligands with Arylpiperazine Structure: A Structure–Kinetics Relationship Study

Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties

Behavioral, Anti-Inflammatory, and Neuroprotective Effects of a Novel FPR2 Agonist in Two Mouse Models of Autism

Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways

The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Improves Ex Vivo and In Vivo Amyloid Beta (1–42)-Induced Neuroinflammation in Mouse Models of Alzheimer’s Disease

Collaborators (8)

Magdalena Regulska

Marcello Leopoldo

Carla Perrone-Capano

Carmen Abate

Agnieszka Basta-Kaim

Marianna CRISPINO

Katarzyna Curzytek

Floriana Volpicelli

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