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Alan Melcher

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Professor of Translational Immunotherapy

Institute of Cancer Research

United Kingdom

Research Interests

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Professors in United Kingdom Professors in Immunology Immunology professors in United Kingdom

Recent Grants

Grant: Close

Dynamics of T-cell-driven responense to radiotherapy in a murine model of melamona

Open Date: 2021-02-01

Close Date: 2021-12-01

Grant: Open

Immunotherapy

Open Date: 2019-10-01

Close Date: 2031-06-01

Grant: Close

BRC Funding - pump priming

Open Date: 2019-04-01

Close Date: 2022-02-01

Grant: Close

Crick Accelerator Clinical Fellowship

Open Date: 2018-09-01

Close Date: 2021-11-01

Grant: Close

Investigation of the Human Immune Response

Open Date: 2018-08-01

Close Date: 2021-07-01

Articles (18)

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Collaborators (28)

Ross Scrimgeour

University Of Strathclyde

UNITED KINGDOM

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Sheeba Irshad

King’s College London

UNITED KINGDOM

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Kok Haw Jonathan Lim

Clinical Senior Lecturer in Cancer Biology

The University of Manchester

UNITED KINGDOM

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George Kassiotis

Imperial College London

UNITED KINGDOM

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Henry G Smith

University of Copenhagen

DENMARK

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Lillian Wu

Institute of Cancer Research

UNITED KINGDOM

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Udai Banerji

Co-Director DDU and Professor of Molecular Cancer Pharmacology

The Institute of Cancer Research & The Royal Marsden NHS Foundation Trust

UNITED KINGDOM

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Masahiro Ono

Professor

Imperial College London

UNITED KINGDOM

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Michael Hubank

Professor of Translational Genomics

University College London

UNITED KINGDOM

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Jyoti Choudhary

Professor of Functional Proteomics

Institute of Cancer Research

UNITED KINGDOM

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Wendy Béguelin

Assistant Professor

NYU School of Medicine

UNITED STATES

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Ben O'Leary

Group Leader

Institute of Cancer Research

UNITED KINGDOM

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Kristian Helin

CEO, Professor

Institute of Cancer Research

UNITED KINGDOM

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Philippe A. Cassier

Université Claude Bernard Lyon 1

FRANCE

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Salvatore Papa

Associate Professor

University of Leeds

UNITED KINGDOM

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Antonio José Rullán

University College London

UNITED KINGDOM

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Shane Foo

Senior Research Fellow

King’s College London

UNITED KINGDOM

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PABLO NENCLARES

Institute of Cancer Research

UNITED KINGDOM

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Andrew Tutt

Professor of Clinical Oncology

Institute of Cancer Research

UNITED KINGDOM

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Amanda Huff

Assistant Professor

Johns Hopkins University

UNITED STATES

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Manuel Salto-Tellez

Lead

Institute of Cancer Research

UNITED KINGDOM

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Dragomir Krastev

Institute of Cancer Research

UNITED KINGDOM

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Kevin Harrington

Head of Division of Radiotherapy and Imaging

Institute of Cancer Research

UNITED KINGDOM

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Pippa Corrie

Cambridge University Hospitals NHS Foundation Trust

UNITED KINGDOM

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Crescens Diane Tiu

Clinical Scientist

Institute of Cancer Research

UNITED KINGDOM

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Jessica Downs

Professor and Deputy Head of Division

Institute of Cancer Research

UNITED KINGDOM

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Grant D. Stewart

University of Cambridge

UNITED KINGDOM

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Alison Taylor

University of Leeds

UNITED KINGDOM

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Alan Melcher

Research Interests

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Recent Grants

Articles (18)

Necroptosis in both tumour and stromal compartments determines responsiveness to immunogenic cell death-based immunotherapy.

Engagement of the TCR against an oncolytic virus generates a population of effector CAR T cells with potent antitumor activity

Effects of oncolytic immunotherapy with RP1 (vusolimogene oderparepvec) on immune cells mediate responsiveness to anti-PD-1 via STING-mediated interferon signaling.

Single versus repeated intravenous oncolytic reovirus infusions: Implications for immune modulation and rationalised scheduling of therapy in hepatocellular carcinoma

Immunodominant Antiviral T Cell Responses Outcompete Antitumor T Cell Responses to Reduce the Efficacy of Oncolytic Viroimmunotherapy

Cancer Immunotherapy Using AIRE Conditioning of the Tumor Epitopeome.

Synergistic antitumor effect of combined EZH2 and DOT1L inhibition in B-cell lymphoma

A Phase I Clinical Trial of Intrahepatic Artery Delivery of TG6002 in Combination with Oral 5-Fluorocytosine in Patients with Liver-Dominant Metastatic Colorectal Cancer

The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models

MANIFEST: Multiomic Platform for Cancer Immunotherapy.

PBRM1 directs PBAF to pericentromeres and protects centromere integrity

The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer.

Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion.

Tumor control and immune activation through palliative irradiation and ATR inhibition, PATRIOT Part C: a phase Ib trial.

Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer

Addition of oncolytic virotherapy to clinical isolated limb perfusion for melanoma and sarcoma activates antitumor immunity

CXCL12-Targeted Immunomodulatory Gene Therapy Reduces Radiation-Induced Fibrosis in Healthy Tissues

Modulating T-cell Responses to Enhance the Effects of Radiotherapy.

Collaborators (28)

Ross Scrimgeour

Sheeba Irshad

Kok Haw Jonathan Lim

George Kassiotis

Henry G Smith

Lillian Wu

Udai Banerji

Masahiro Ono

Michael Hubank

Jyoti Choudhary

Wendy Béguelin

Ben O'Leary

Kristian Helin

Philippe A. Cassier

Salvatore Papa

Antonio José Rullán

Shane Foo

PABLO NENCLARES

Andrew Tutt

Amanda Huff

Manuel Salto-Tellez

Dragomir Krastev

Kevin Harrington

Pippa Corrie

Crescens Diane Tiu

Jessica Downs

Grant D. Stewart

Alison Taylor

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