Alexandra Antunes

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Assistant Professor

Instituto Superior Técnico

Portugal

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About

Alexandra Antunes is an Assistant Professor at Instituto Superior Técnico in Portugal. Her research primarily focuses on the cytotoxicity of synthetic compounds, biotransformation processes, and the development of novel anticancer agents. Recent works include studies on the cytotoxic effects of synthetic cathinones, as well as investigations into p53-targeting small molecules and novel metal complexes with therapeutic potential against various cancer types.

Recent Grants

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Mass spectrometry & Machine Learning pipeline to tackle Chronic Kidney Disease & Resistant Hypertension: a guide for patient subtyping & precision medicine

Open Date: 2023-02-01

Close Date: 2024-08-31

Grant: Close

Gender-specificity of N-Acetyl-2-aminofluorene (AAF)-induced liver carcinogenesis: Can Histone modifications have a role?

Open Date: 2021-01-01

Close Date:

Grant: Close

Chemically-induced cancer: new early biomarkers

Open Date: 2020-01-01

Close Date:

Grant: Close

Launching the Breakthrough in Lupus Diagnostics

Open Date: 2019-01-01

Close Date: 2019-01-01

Grant: Close

Drug discovery for p53 ppi-targets

Open Date: 2019-01-01

Close Date:

Articles (19)

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2021

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2021

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2021

Collaborators (25)

Sofia Catarino

Universidade de Aveiro

PORTUGAL

Alexandra Antunes

Research Interests

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About

Recent Grants

Articles (19)

Mechanistic Insights of a p53-Targeting Small Molecule

Monoterpenoid selenophenes derived from (−)-carvone with GPx-like activity

Novel 8-Hydroxyquinoline-Derived V(IV)O, Ni(II), and Fe(III) Complexes: Synthesis, Characterization, and In Vitro Cytotoxicity Against Tumor Cells

Biotransformation of ketamine in terminal in vivo experiments under chronic intermittent hypoxia conditions and the role of AhR

The cytotoxicity of synthetic cathinones on dopaminergic-differentiated SH-SY5Y neuroblastoma cell line: Exploring the role of β-keto metabolic reduction

Bioinspired copper-catalysed nitrous oxide reduction with simultaneous N–H or O–H bond oxidation

Lead to hit ruthenium-cyclopentadienyl anticancer compounds: Cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling

Carcinogenicity of hydrochlorothiazide, voriconazole, and tacrolimus.

Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators

New Ruthenium-Cyclopentadienyl Complexes Affect Colorectal Cancer Hallmarks Showing High Therapeutic Potential

Metabolic stability and metabolite profiling of emerging synthetic cathinones

First Chemical Profile Analysis of Acacia Pods

Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine

Glycidamide and cis-2-butene-1,4-dial (BDA) as potential carcinogens and promoters of liver cancer - An in vitro study

Identification of gallotannins and ellagitannins in aged wine spirits: A new perspective using alternative ageing technology and high-resolution mass spectrometry

Covalent Histone Modification by an Electrophilic Derivative of the Anti-HIV Drug Nevirapine

The 2-hydroxy-nevirapine metabolite as a candidate for boosting apolipoprotein A1 and for modulating anti-HDL antibodies

Tryptophanol-Derived Oxazolopyrrolidone Lactams as Potential Anticancer Agents against Gastric Adenocarcinoma

Human Cystathionine γ-Lyase Is Inhibited by s-Nitrosation: A New Crosstalk Mechanism between NO and H2S

Collaborators (25)

Sofia Catarino

Catarina Reis

Elisabete Alegria

Andreia Valente

Ana Preto

Maria Santos

Sofia de Azeredo Pereira

Judit Morello

Jacinta Serpa

Nuno Coelho

Maria Armanda Viana Rodrigues

Joaquim Calado

Gonçalo C. Justino

Luísa Teixeira-Santos

Catarina Roma-Rodrigues

Emília Carreira Monteiro

Victor Freitas

Ofélia Anjos

José Gonçalves

Paula Leandro

Agnès Fournier

Alexandra Fernandes

Lucília Saraiva

Luis Filipe Veiros

M. Matilde Marques

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