Alfred Vertegaal

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Professor

Leiden University

Netherlands

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Recent Grants

Grant: Close

Cracking the SUMO Signalling Code

Open Date: 2013-01-01

Close Date: 2017-12-31

Grant: Close

The Ubiquitin-Proteasome System is a Key Component of the Cellular SUMO-2/3 Cycle

Open Date:

Close Date:

Grant: Close

Uncovering the role of sumoylation in pre-mRNA splicing

Open Date:

Close Date:

Grant: Close

Cracking the Mitotic SUMO-Phospho Signaling Code

Open Date:

Close Date:

Articles (16)

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2024

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2021

Collaborators (13)

Peter van Veelen

Leiden University Medical Center

NETHERLANDS

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Tanveer Singh Batth

Københavns Universitet

DENMARK

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Blagoy Blagoev

University of Southern Denmark

DENMARK

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Bharath Sampadi

Leiden University Medical Center

NETHERLANDS

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Girish Shah

Laval University

CANADA

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Jurgen Marteijn

Full Professor

Erasmus MC

NETHERLANDS

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Gerbrand van der Heden van Noort

Assistant professor (Principal Investigator)

Leiden University Medical Center

NETHERLANDS

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Remco van Doorn

Leiden University Medical Center

NETHERLANDS

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Mirjam H.M. Heemskerk

Associate professor, Head of Laboratory of experimental hematology

Leiden University Medical Center

NETHERLANDS

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Noel de Miranda

Professor

Leiden University Medical Center

NETHERLANDS

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Román González-Prieto

Leiden University Medical Center

NETHERLANDS

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Lucia Daxinger

Leiden University Medical Center

NETHERLANDS

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Peter ten Dijke

Leiden University Medical Center

NETHERLANDS

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Alfred Vertegaal

Research Interests

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Recent Grants

Articles (16)

SUMO proteases: from cellular functions to disease

Inhibition of SUMOylation enhances DNA hypomethylating drug efficacy to reduce outgrowth of hematopoietic malignancies

The lncRNA LETS1 promotes TGF-β–induced EMT and cancer cell migration by transcriptionally activating a TβR1-stabilizing mechanism

BioE3 identifies specific substrates of ubiquitin E3 ligases

SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation

Exome sequencing links the SUMO protease SENP7 with fatal arthrogryposis multiplex congenita, early respiratory failure and neutropenia

A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair

In-plate Chemical Synthesis of Isopeptide-linked SUMOylated Peptide Fluorescence Polarization Reagents for High-Throughput Screening of SENP preferences.

Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model

Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation

Signalling mechanisms and cellular functions of SUMO

Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates

A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair.

Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention

Identification of proximal SUMO-dependent interactors using SUMO-ID.

Site-specific proteomic strategies to identify ubiquitin and SUMO modifications: Challenges and opportunities.

Collaborators (13)

Peter van Veelen

Tanveer Singh Batth

Blagoy Blagoev

Bharath Sampadi

Girish Shah

Jurgen Marteijn

Gerbrand van der Heden van Noort

Remco van Doorn

Mirjam H.M. Heemskerk

Noel de Miranda

Román González-Prieto

Lucia Daxinger

Peter ten Dijke

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