Mirjam H.M. Heemskerk

Associate professor, Head of Laboratory of experimental hematology

Leiden University Medical Center

Netherlands

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Research Interests

Immunology

100%

Cell Biology

80%

T Cell Biology

70%

Immunotherapy

50%

Dendritic Cell

40%

Cancer Biology

40%

Epigenetic

20%

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Swammerdamprijs

Open Date: 2011-01-01

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Articles13

TCR targeting hematopoiesis to cure leukemia

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Year:

2024

Balanced Epigenetic Regulation of MHC Class I Expression in Tumor Cells by the Histone Ubiquitin Modifiers BAP1 and PCGF1

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Year:

2024

Chimeric HLA antibody receptor T cells to target HLA‐specific B cells in solid organ transplantation

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Year:

2023

Combining BCMA-targeting CAR-T with TCR-engineered T-cell therapy to prevent immune escape of multiple myeloma

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Year:

2023

Inhibition of SUMOylation enhances DNA hypomethylating drug efficacy to reduce outgrowth of hematopoietic malignancies

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Year:

2023

SARS‐CoV‐2 mRNA vaccination of aplastic anemia patients is safe and effective

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Year:

2023

Human CD34+-derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8+ T cell and NK cell responses in vitro and in vivo

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Year:

2023

Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

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Year:

2022

T cell receptor engineering of primary NK cells to therapeutically target tumors and tumor immune evasion

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Year:

2022

An HLA-A*11:01-Binding Neoantigen from Mutated NPM1 as Target for TCR Gene Therapy in AML

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Year:

2021

Clinically applicable CD34+-derived blood dendritic cell subsets exhibit key subset-specific features and potently boost anti-tumor T and NK cell responses

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Year:

2021

Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues

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Year:

2020

Immunopeptidome Analysis of HLA-DPB1 Allelic Variants Reveals New Functional Hierarchies

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Year:

2020

Collaborators11

Marieke Griffioen

Associate Professor

Leiden University Medical Center

NETHERLANDS

Tassilo Leo Alexander Wachsmann

Leiden University Medical Center

NETHERLANDS

Tom H. M. Ottenhoff

Leiden University Medical Center

NETHERLANDS

Jan Wouter Drijfhout

Leiden University Medical Center

NETHERLANDS

Alfred Vertegaal

Professor

Leiden University

NETHERLANDS

Sebastiaan Heidt

Associate Professor

Leiden University Medical Center

NETHERLANDS

Jannie Borst

Leiden University Medical Center

NETHERLANDS

Yanling Xiao

Assistant Professor

Leiden University Medical Center

NETHERLANDS

Jeanette Leusen

professor

University Medical Center Groningen

NETHERLANDS

Jurgen Kuball

UMC Utrecht

NETHERLANDS

Hendrik Veelken

NETHERLANDS

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