Scott Franzblau

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Professor and Director

University of Illinois Chicago (UIC)

United States

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About

Scott Franzblau is a Professor and Director at the University of Illinois Chicago, United States. His research focuses on the discovery and development of novel antimicrobial agents, particularly targeting Mycobacterium tuberculosis and various parasitic infections. Recent publications include investigations into natural-product-derived compounds and optimization of existing drug classes to enhance efficacy against tuberculosis and related diseases.

Recent Grants

Grant: Close

Modulation of Protein production and Degradation as an integrated approach to rapid sterilization of Drug sensitive and resistant Mtb.

Open Date: 2019-04-01

Close Date: 2024-03-31

Grant: Close

Development of Diazaquinomycin Class Antibiotics for the Treatment of Drug-Resistant TB Infections

Open Date: 2013-07-15

Close Date: 2016-07-14

Grant: Close

In vitro detection of anti-TB liver metabolites in early drug discovery

Open Date: 2012-02-15

Close Date: 2015-01-31

Grant: Close

Lead identification of 1,4-benzoxazines as anti-tuberculosis agents

Open Date: 2006-09-20

Close Date: 2009-08-31

Grant: Close

Evaluation of in vitro radiorespirometric systems in screening for antileprosy drugs

Open Date: 1989-11-21

Close Date: 1991-05-23

Articles (10)

Year:

2025

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2024

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2024

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2023

Year:

2023

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2022

Year:

2022

Year:

2022

Year:

2022

Year:

2021

Collaborators (8)

Hollis Showalter

Research Professor Emeritus of Medicinal Chemistry

University of Michigan

UNITED STATES

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Amanda Fortes Francisco

Assistant Professor

London School of Hygiene & Tropical Medicine

UNITED KINGDOM

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Alexey Rak

Head of Department

FRANCE

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Nicholas P. West

AUSTRALIA

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George A. Garcia

UNITED STATES

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Guo-Liang Lu

University of Auckland

NEW ZEALAND

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Heonjoong Kang

Seoul National University

SOUTH KOREA

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Colin Jackson

Associate Professor

Australian National University

AUSTRALIA

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Scott Franzblau

Research Interests

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About

Recent Grants

Articles (10)

Nifuroxazide and 4-Hydroxybenzhydrazone Derivatives as New Antiparasitic (Trypanosoma cruzi and Leishmania mexicana) and Anti-Mycobacterium tuberculosis Agents

Cavomycins A–C, Linear Oligomer Depsipeptides from an Annelid-Associated <i>Streptomyces cavourensis</i>

Expanding the chemical space of ester of quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives as potential antitubercular agents

Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.

Isolation and Characterization of Anti-Mycobacterial Natural Products from a Petrosia sp. Marine Sponge

Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection

Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis

Optimization of Benzoxazinorifamycins to Minimize hPXR Activation for the Treatment of Tuberculosis and HIV Coinfection

Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis

Chemical Diversity and Antimicrobial Potential of Cultivable Fungi from Deep-Sea Sediments of the Gulf of Mexico

Collaborators (8)

Hollis Showalter

Amanda Fortes Francisco

Alexey Rak

Nicholas P. West

George A. Garcia

Guo-Liang Lu

Heonjoong Kang

Colin Jackson

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