Ana Martinez

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Profesor de Investigación OPI

Consejo Superior de Investigaciones Cientificas

Spain

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Ana Martinez is a Profesor de Investigación OPI at the Consejo Superior de Investigaciones Científicas in Spain. Her research focuses on neuroinflammation, neuroprotection, and drug discovery, as evident in her recent work involving SGK1 inhibitors and Sphingosine-1-Phosphate receptor modulators. She is also exploring potential therapeutics for tauopathies and amyotrophic lateral sclerosis, utilizing advanced virtual screening and molecular dynamics simulations.

Recent Grants

Grant: Open

FragScreen, From fragments to high affinity binders interfacing integrated structural biology, medicinal chemistry and artificial intelligence

Open Date: 2023-03-01

Close Date: 2027-03-01

Grant: Close

Inhibidores de TTBK1 como posible tratamiento innovador para la demencia frontotemporal

Open Date: 2023-01-01

Close Date: 2024-12-01

Grant: Close

SGK4PD: Fighting against Parkinson's Disease with SGK1 inhibitors

Open Date: 2022-12-01

Close Date: 2024-11-01

Grant: Close

Drugs4ALS: Targeting TDP-43 with protein kinase inhibitors: an effective and measurable therapy for ALS

Open Date: 2021-11-01

Close Date: 2024-11-01

Grant: Close

Modulación del envejecimiento y la neurodegeneración por moléculas pequeñas inhibidoras de proteína quinasa

Open Date: 2020-06-01

Close Date: 2024-06-01

Articles (19)

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2022

Collaborators (10)

Diego Muñoz-Torrero

Full Professor of Organic & Medicinal Chemistry

University of Barcelona

SPAIN

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Javier Recio

Assistant Professor

Universidad Rey Juan Carlos

SPAIN

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I.J.P. de Esch

University of Amsterdam

NETHERLANDS

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Patricia Boya

Full Professor

University of Fribourg

SWITZERLAND

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Sebastian Guettler

Professor of Structural Biology and Cell Signalling

Institute of Cancer Research

UNITED KINGDOM

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Eeva-Liisa Eskelinen

University of Helsinki

FINLAND

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Inmaculada Galindo

SPAIN

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Rob Leurs

University of Amsterdam

NETHERLANDS

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Koen Augustyns

Full Professor

University of Antwerp

BELGIUM

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Guy Caljon

Prof.

University of Antwerp

BELGIUM

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Ana Martinez

Research Interests

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About

Recent Grants

Articles (19)

Discovery of a brain penetrant SGK1 inhibitor using a ligand- and structure-based virtual screening methodology

Discovery of Sphingosine-1-Phosphate Receptor Modulators as Potential CHI3L1 Inhibitors by Ligand-Based Virtual Screening and Molecular Dynamics Simulations

<sup>11</sup>C-Labeling of a Flavanone Extracted from a South American Native Species for Evaluation of Its Interaction with GSK-3β

RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection

Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase

Discovery of Thiophene Derivatives as Potent, Orally Bioavailable, and Blood–Brain Barrier-Permeable Ebola Virus Entry Inhibitors

Efficacy of a benzothiazole‐based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis

Proteome Aggregation in Cells Derived from Amyotrophic Lateral Sclerosis Patients for Personalized Drug Evaluation

Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

Identification of a new structural family of SGK1 inhibitors as potential neuroprotective agents

The emerging role of mixed lineage kinase 3 (MLK3) and its potential as a target for neurodegenerative diseases therapies

N'-Phenylacetohydrazide Derivatives as Potent Ebola Virus Entry Inhibitors with an Improved Pharmacokinetic Profile

To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?

Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions

Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts

Emerging clinical investigational drugs for the treatment of amyotrophic lateral sclerosis

The mechanism of macroautophagy: The movie

Efficacy of Bromhexine versus Standard of Care in Reducing Viral Load in Patients with Mild-to-Moderate COVID-19 Disease Attended in Primary Care: A Randomized Open-Label Trial

The Dual PDE7-GSK3β Inhibitor, VP3.15, as Neuroprotective Disease-Modifying Treatment in a Model of Primary Progressive Multiple Sclerosis

Collaborators (10)

Diego Muñoz-Torrero

Javier Recio

I.J.P. de Esch

Patricia Boya

Sebastian Guettler

Eeva-Liisa Eskelinen

Inmaculada Galindo

Rob Leurs

Koen Augustyns

Guy Caljon

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