Diego Muñoz-Torrero

Full Professor of Organic & Medicinal Chemistry

University of Barcelona

Spain

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About

Diego Muñoz-Torrero is a Full Professor of Organic & Medicinal Chemistry at the University of Barcelona, Spain. His research focuses on the interactions of proteins and therapeutic agents in the context of diseases such as Alzheimer's and malaria. Recent work includes investigating proteome aggregation in ALS patients, developing anti-Alzheimer compounds, and exploring the antimalarial potential of aggregated protein dyes.

Articles (18)

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2024

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2020

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2020

Collaborators (32)

Jussara Amato

University of Naples Federico II

ITALY

Diego Muñoz-Torrero

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Articles (18)

Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties

Effect of the aggregated protein dye YAT2150 on Leishmania parasite viability

Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets

Leveraging the Aggregated Protein Dye YAT2150 for Malaria Chemotherapy

Proteome Aggregation in Cells Derived from Amyotrophic Lateral Sclerosis Patients for Personalized Drug Evaluation

Chlorpyrifos Oxon Activates Glutamate and Lysine for Protein Cross-linking

A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer's disease exacerbated with high fat diet.

A rhein-huprine hybrid protects erythrocyte membrane integrity against Alzheimer’s disease related Aβ(1-42) peptide

A Combined Chronic Low-Dose Soluble Epoxide Hydrolase and Acetylcholinesterase Pharmacological Inhibition Promotes Memory Reinstatement in Alzheimer’s Disease Mice Models

Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer’s Disease

Unveiling the Multitarget Anti-Alzheimer Drug Discovery Landscape: A Bibliometric Analysis

The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures

From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects

Clock/Sleep-Dependent Learning and Memory in Male 3xTg-AD Mice at Advanced Disease Stages and Extrinsic Effects of Huprine X and the Novel Multitarget Agent AVCRI104P3

Protective Role of a Donepezil-Huprine Hybrid against the β-Amyloid (1-42) Effect on Human Erythrocytes

The Cream of the Crop of the Medicinal Chemistry Section of Molecules—2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

Collaborators (32)

Jussara Amato

George Kokotos

Maurizio Pellecchia

María Isabel Loza García

Amanda Cano

Christian Griñán Ferré

Michael Gütschow

Carles Galdeano

Giuseppe Legname

Valentín Iglesias

Ana Martinez

Massimo Bertinaria

Manuela Bartolini

STEFANO MANGANI

Elisabet Teixido

Miren Ettcheto

Jose Brea

Belén Pérez

Sandra Pérez Torras

Santiago Vazquez

Oksana Lockridge

F. Javier Pérez-Areales

Katalin Prokai-Tatrai

Ondrej Soukup

Ivan Kosalec

Ludovic Jean

Mercè Pallàs

Pelayo Camps

Yasu-Taka Azuma

Jordi Olloquequi

Peter Scott

Jarkko Rautio

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