Andrew Leach

The University of Manchester

United Kingdom

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Articles (16)

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2025

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2025

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2024

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2021

Collaborators (14)

Benjamin Buckley

Reader

Loughborough University

UNITED KINGDOM

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Michael Waring

Professor of Medicinal Chemistry

Newcastle University

UNITED KINGDOM

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Guy C. Lloyd-Jones

University of Edinburgh

UNITED KINGDOM

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Sally Freeman

Lecturer, Senior Lecturer Reader

The University of Manchester

UNITED KINGDOM

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Tessa Swanton

The Francis Crick Institute

UNITED KINGDOM

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Martin Lowe

UNITED KINGDOM

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Sam Butterworth

The University of Manchester

UNITED KINGDOM

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John Fossey

Professor of Synthetic Chemistry

University of Birmingham

UNITED KINGDOM

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Ulrich Zachariae

UNITED KINGDOM

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Joanna M. Zarnecka

Wroclaw University of Science and Technology

POLAND

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Jack Green

The University of Manchester

UNITED KINGDOM

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M Jayne Lawrence

The University of Manchester

UNITED KINGDOM

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Richard Campbell

The University of Manchester

UNITED KINGDOM

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David Brough

The University of Manchester

UNITED KINGDOM

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Andrew Leach

Research Interests

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Articles (16)

Dynamic self-assembled meso-structures formed across a wide concentration range in aqueous solutions of propranolol hydrochloride

Design and synthesis of a chemically diverse, lead-like DNA-encoded library from sequential amide coupling

Photoswitchable Azobispyrazole Crystals Achieving Near-Quantitative Crystalline-State Bidirectional E ⇆ Z Conversions

Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome

Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium

The Pathological Effects of Circulating Hydrophobic Bile Acids in Alzheimer's Disease

In Situ Studies of Arylboronic Acids/Esters and R3SiCF3 Reagents: Kinetics, Speciation, and Dysfunction at the Carbanion–Ate Interface

Data-Driven Derivation of Molecular Substructures That Enhance Drug Activity in Gram-Negative Bacteria

Asymmetric Synthesis of Heterocyclic Chloroamines and Aziridines by Enantioselective Protonation of Catalytically Generated Enamines**

Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles

A Lewis Base Nucleofugality Parameter, NFB, and Its Application in an Analysis of MIDA-Boronate Hydrolysis Kinetics

Heavy-Atom Kinetic Isotope Effects: Primary Interest or Zero Point?

Protodeboronation of (Hetero)Arylboronic Esters: Direct versus Prehydrolytic Pathways and Self-/Auto-Catalysis

Mapping Ligand-Shape Space for Protein–Ligand Systems: Distinguishing Key-in-Lock and Hand-in-Glove Proteins

Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles

Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity

Collaborators (14)

Benjamin Buckley

Michael Waring

Guy C. Lloyd-Jones

Sally Freeman

Tessa Swanton

Martin Lowe

Sam Butterworth

John Fossey

Ulrich Zachariae

Joanna M. Zarnecka

Jack Green

M Jayne Lawrence

Richard Campbell

David Brough

Make your next move.