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Andrew Leach

The University of Manchester

United Kingdom

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Research Interests

Organic Chemistry

60%

Pharmaceutical Chemistry

20%

Cycloaddition Reactions

40%

Chemical Biology

30%

Heterocyclic Chemistry

30%

Chemical Synthesis

20%

Supramolecular Chemistry

20%

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Articles16

Dynamic self-assembled meso-structures formed across a wide concentration range in aqueous solutions of propranolol hydrochloride

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Year:

2025

Design and synthesis of a chemically diverse, lead-like DNA-encoded library from sequential amide coupling

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Year:

2025

Photoswitchable Azobispyrazole Crystals Achieving Near-Quantitative Crystalline-State Bidirectional E ⇆ Z Conversions

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Year:

2024

Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome

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Year:

2023

Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium

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Year:

2023

The Pathological Effects of Circulating Hydrophobic Bile Acids in Alzheimer's Disease

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Year:

2023

In Situ Studies of Arylboronic Acids/Esters and R3SiCF3 Reagents: Kinetics, Speciation, and Dysfunction at the Carbanion–Ate Interface

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Year:

2022

Data-Driven Derivation of Molecular Substructures That Enhance Drug Activity in Gram-Negative Bacteria

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Year:

2022

Asymmetric Synthesis of Heterocyclic Chloroamines and Aziridines by Enantioselective Protonation of Catalytically Generated Enamines**

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Year:

2022

Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles

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Year:

2022

A Lewis Base Nucleofugality Parameter, NFB, and Its Application in an Analysis of MIDA-Boronate Hydrolysis Kinetics

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Year:

2022

Heavy-Atom Kinetic Isotope Effects: Primary Interest or Zero Point?

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Year:

2021

Protodeboronation of (Hetero)Arylboronic Esters: Direct versus Prehydrolytic Pathways and Self-/Auto-Catalysis

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Year:

2021

Mapping Ligand-Shape Space for Protein–Ligand Systems: Distinguishing Key-in-Lock and Hand-in-Glove Proteins

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Year:

2021

Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles

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Year:

2021

Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity

Article Link

Year:

2021

Collaborators14

Benjamin Buckley

Reader

Loughborough University

UNITED KINGDOM

Michael Waring

Professor of Medicinal Chemistry

Newcastle University

UNITED KINGDOM

Guy C. Lloyd-Jones

University of Edinburgh

UNITED KINGDOM

Sally Freeman

Lecturer, Senior Lecturer Reader

The University of Manchester

UNITED KINGDOM

Tessa Swanton

The Francis Crick Institute

UNITED KINGDOM

Martin Lowe

UNITED KINGDOM

Sam Butterworth

The University of Manchester

UNITED KINGDOM

John Fossey

Professor of Synthetic Chemistry

University of Birmingham

UNITED KINGDOM

Ulrich Zachariae

UNITED KINGDOM

Joanna M. Zarnecka

Wroclaw University of Science and Technology

POLAND

Jack Green

The University of Manchester

UNITED KINGDOM

M Jayne Lawrence

The University of Manchester

UNITED KINGDOM

Richard Campbell

The University of Manchester

UNITED KINGDOM

David Brough

The University of Manchester

UNITED KINGDOM

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