Sally Freeman

Lecturer, Senior Lecturer Reader

The University of Manchester

United Kingdom

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Sally Freeman is a lecturer at the University of Manchester in the UK. Her research primarily focuses on the role of the NLRP3 inflammasome in various inflammatory and cancer-related pathways, as evidenced by her recent articles on inflammatory responses and potential therapeutic inhibitors. Additionally, she investigates mechanistic insights into chloride channels related to drug resistance and disease modulation.

Articles (16)

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2025

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2021

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2020

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2020

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Jim Warwicker

The University of Manchester

UNITED KINGDOM

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Annalisa Tirella

UNITED KINGDOM

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Jack Green

The University of Manchester

UNITED KINGDOM

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Kevin Couper

Professor

The University of Manchester

UNITED KINGDOM

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David Brough

The University of Manchester

UNITED KINGDOM

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Sally Freeman

Research Interests

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Articles (16)

Understanding a Potential Role for the NLRP3 Inflammasome in Placenta‐Mediated Pregnancy Complications

Discovery of Potent Benzothiazole Inhibitors of Oxidoreductase NQO2, a Target for Inflammation and Cancer

Virtual screening-led design of inhibitor scaffolds for the NLRP3 inflammasome

Brazilin is a Natural Product Inhibitor of the NLRP3 Inflammasome

Evaluation of 4-Aminoquinoline Hydrazone Analogues as Potential Leads for Drug-Resistant Malaria

Computational Investigation of Mechanisms for pH Modulation of Human Chloride Channels

Tadalafil Rescues the p.M325T Mutant of Best1 Chloride Channel

Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome

Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium

Probing the effect of NEK7 and cofactor interactions on dynamics of NLRP3 monomer using molecular simulation

A Selective Review and Virtual Screening Analysis of Natural Product Inhibitors of the NLRP3 Inflammasome

SAR of Novel 3-Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules

Selected Derivatives of Erythromycin B-In Silico and Anti-Malarial Studies

Inhibiting the NLRP3 Inflammasome

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

Resveratrol-mediated cleavage of amyloid β1–42 peptide: potential relevance to Alzheimer's disease

Collaborators (13)

Richard Bryce

Forbes Manson

Neil Humphreys

Tessa Swanton

Martin Lowe

Andrew Leach

Niroshini Nirmalan

Alexander E. P. Heazell

Jim Warwicker

Annalisa Tirella

Jack Green

Kevin Couper

David Brough

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