Aurélie Carlier

This PhD project is part of EDI-MSK , a European Marie Skłodowska-Curie Actions Doctoral Network focused on making musculoskeletal modelling more inclusive, personalised and clinically relevant. The project addresses an important challenge in musculoskeletal health: understanding how diversity, bias, and biological variation should be reflected in next-generation models of bone and related tissues. The specific doctoral project (DC6) aims to develop multiscale models of how chronic kidney disease affects bone healing and remodelling . You will work on identifying the mechanisms by which uremic toxins influence bone regeneration through network models of cells and signalling pathways, then connect these biological effects with biomechanical models of healing and remodelling. The final goal is to build computational tools that can predict differences in fracture healing under realistic lower-limb conditions for patients with chronic kidney disease. The project sits within a large interdisciplinary European consortium of 20 organisations across 10 countries, bringing together expertise in biomedical science, engineering, imaging, simulation, experimental work, and clinical research. As a doctoral candidate, you will join a cohort of researchers working across academia and industry, with collaboration spanning Maastricht University, other European universities, and the Society for In Silico Medicine. At Maastricht University, the project is based in the Maastricht Centre for Systems Biology and Bioinformatics (MaCSBio) . The centre is described as a research environment dedicated to understanding, simulating, and manipulating biological systems using advanced mathematical and computational methods, with current themes including systems biomedicine and computational neuroscience. You will work as part of a multidisciplinary team of modelling and simulation experts and musculoskeletal researchers, and you will also have supervision involvement from the University of Padua. The role is strongly research-oriented and combines computational modelling, simulation, and interdisciplinary collaboration. It offers access to international training, advanced infrastructure, and a network designed to develop future leaders in musculoskeletal health research.