Benedetta Bussolati

Associate Professor of Nephrology

University of Turin

Italy

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About

Dr. Benedetta Bussolati is an Associate Professor of Nephrology at the University of Torino, Italy. Her research focuses on the role of extracellular vesicles in various kidney-related conditions, including renal fibrosis, kidney inflammation, and pediatric kidney diseases. She has published extensively on innovative liquid biopsy methods and biomarkers for colorectal cancer and pulmonary arterial hypertension, emphasizing the clinical applications of extracellular vesicle profiling.

Articles (25)

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2025

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2025

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2025

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2025

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2025

The early identification of a subclinical rejection (SCR) can improve the long-term outcome of the transplanted kidney through intensified immunosuppression. However, the only approved diagnostic method is the protocol biopsy, which remains an invasive method and not without minor and/or major complications. The protocol biopsy is defined as the sampling of allograft tissue at pre-established times even in the absence of an impaired renal function; however, it does not avoid histological damage. Therefore, the discovery of new possible biomarkers useful in the prevention of SCR has gained great interest. Among all the possible candidates, there are microRNAs (miRNAs), which are short, noncoding RNA sequences, that are involved in mediating numerous post-transcriptional pathways. They can be found not only in tissues, but also in different biological fluids, both as free particles and contained in extracellular vesicles (EVs) released by different cell types. In this study, we firstly performed a retrospective miRNA screening analysis on biopsies and serum EV samples of 20 pediatric transplanted patients, followed by a second screening on another 10 pediatric transplanted patients’ urine samples at one year post-transplant. In both cohorts, we divided the patients into two groups: patients with histological SCR and patients without histological SCR at one year post-transplantation. The isolated miRNAs were analyzed in an NGS platform to identify different expressions in the two allograft states. Although no statistical data were found in sera, in the tissue and urinary EVs, we highlighted signatures of miRNAs associated with the histological SCR state.

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2024

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2024

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2024

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2021

Collaborators (103)

VIKRAMSINGH GUJAR

Assistant Professor

University of Oklahoma Health Sciences Center

UNITED STATES

Benedetta Bussolati

Research Interests

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About

Articles (25)

Single-Vesicle Molecular Profiling by dSTORM Imaging in a Liquid Biopsy Assay Predicts Early Relapse in Colorectal Cancer

Roadblocks of Urinary EV Biomarkers: Moving Toward the Clinic

Proteomics of Urinary Extracellular Vesicles Highlight the Involvement of Vitronectin and the Fibrinolytic and TNF Pathways as Mechanisms Underlying Renal Fibrosis in Kidney Transplant Patients

Urinary Extracellular Vesicle Analysis Reveals Early Signs of Kidney Inflammation and Damage in Single Ventricle Paediatric Patients After Fontan Operation

Extracellular Vesicles as a Potential Biomarker of Pulmonary Arterial Hypertension in Systemic Sclerosis

New Insights into Pediatric Kidney Transplant Rejection Biomarkers: Tissue, Plasma and Urine MicroRNAs Compared to Protocol Biopsy Histology

Standardized Method to Functionalize Plasma-Extracellular Vesicles via Copper-Free Click Chemistry for Targeted Drug Delivery Strategies

A Novel Liquid Biopsy Method Based on Specific Combinations of Vesicular Markers Allows Us to Discriminate Prostate Cancer from Hyperplasia

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.

Extracellular vesicle analytical science loses a touch of creativity and kindness

Extracellular vesicles in kidney development and pediatric kidney diseases

International Society for Extracellular Vesicles Workshop. QuantitatEVs: multiscale analyses, from bulk to single extracellular vesicle.

Plasma Pattern of Extracellular Vesicles Isolated from Hepatitis C Virus Patients and Their Effects on Human Vascular Endothelial Cells

Mesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

Exploring the role of urinary extracellular vesicles in kidney physiology, aging, and disease progression

Glyoxal acid-free (GAF) histological fixative is a suitable alternative to formalin: results from an open-label comparative non-inferiority study.

Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Promote Corneal Wound Repair by Regulating Inflammation and Angiogenesis

Upregulation of miR145 and miR126 in EVs from Renal Cells Undergoing EMT and Urine of Diabetic Nephropathy Patients

Extracellular vesicles in kidney disease

A Novel Xeno-Free Method to Isolate Human Endometrial Mesenchymal Stromal Cells (E-MSCs) in Good Manufacturing Practice (GMP) Conditions

Quinagolide Treatment Reduces Invasive and Angiogenic Properties of Endometrial Mesenchymal Stromal Cells

Generation of Spike-Extracellular Vesicles (S-EVs) as a Tool to Mimic SARS-CoV-2 Interaction with Host Cells

Surface Marker Expression in Small and Medium/Large Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Naive or Apoptotic Condition Using Orthogonal Techniques

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Pass through the Filtration Barrier and Protect Podocytes in a 3D Glomerular Model under Continuous Perfusion

Novel Human Podocyte Cell Model Carrying G2/G2 APOL1 High-Risk Genotype

Collaborators (103)

VIKRAMSINGH GUJAR

Maria Felice Brizzi

Ramaroson Andriantsitohaina

Pier Paolo Sainaghi

Oscar Wiklander

Pia Siljander

Elena Martens-Uzunova

Michele Zanoni

Eduardo Reátegui

Sveva Bollini

Kirsty Danielson

Miguel Flores-Bellver

Anna Krasnodembskaya

Lucia Paolini

Jameel Inal

Manuela Basso

Julie Saugstad

Andrea Roberto Carosso

Federica Collino

Irina Nazarenko

Marta Garcia-Contreras

Fatemeh Momen-Heravi

Albano Caceres-Verschae

Mario Pirisi

Giovanni Camussi

Jennifer Jones

Maiken Mellergaard

Kimberley Louise Alexander

Christian Neri

Ann M Wehman

Lesley Cheng

Donato Colangelo

Rachel Crossland

Daniel Kim

Suman Dutta

Deborah Goberdhan

Carlo Smirne

Roberta Tasso

FRANCESC E. BORRAS

Jason Webber

Mona Batish

Aurélie Ledreux

Tsuneya Ikezu

Cécile MALNOU

Mikael Klingeborn

John Miklavcic

Elena Grossini

Ayesha Saleem